Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects

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dc.citation.volume1
dc.contributor.authorBallerini L
dc.contributor.authorMcGrory S
dc.contributor.authorHernández M
dc.contributor.authorLovreglio R
dc.contributor.authorPellegrini E
dc.contributor.authorMuñoz Maniega S
dc.contributor.authorHenderson R
dc.contributor.authorTaylor A
dc.contributor.authorBastin ME
dc.contributor.authorDoubal F
dc.contributor.authorTrucco E
dc.contributor.authorDeary IJ
dc.contributor.authorWardlaw J
dc.contributor.authorMacGillivray T
dc.date.available2020-08-21
dc.date.issued2020-08-21
dc.description.abstractBackground Perivascular Spaces (PVS) become increasingly visible with advancing age on brain MRI, yet their relationship to morphological changes in the underlying microvessels remains poorly understood. Retinal and cerebral microvessels share morphological and physiological properties. We compared computationally-derived PVS morphologies with retinal vessel morphologies in older people. Methods We analysed data from community-dwelling individuals who underwent multimodal brain MRI and retinal fundus camera imaging at mean age 72.55 years (SD=0.71). We assessed centrum semiovale PVS computationally to determine PVS total volume and count, and mean per-subject individual PVS length, width and size. We analysed retinal images using the VAMPIRE software suite, obtaining the Central Retinal Artery and Vein Equivalents (CRVE and CRAE), Arteriole-to-Venule ratio (AVR), and fractal dimension (FD) of both eyes. We investigated associations using general linear models, adjusted for age, gender, and major vascular risk factors. Results In 381 subjects with all measures, increasing total PVS volume and count were associated with decreased CRAE in the left eye (volume β=−0.170, count β=−0.184, p<0.001). No associations of PVS with CRVE were found. The PVS total volume, individual width and size increased with decreasing FD of the arterioles (a) and venules (v) of the left eye (total volume: FDa β=−0.137, FDv β=−0.139, p<0.01; width: FDa β=−0.144, FDv β=−0.158, p<0.01; size: FDa β=−0.157, FDv β=−0.162, p<0.01). Conclusions Increase in PVS number and size visible on MRI reflect arteriolar narrowing and lower retinal arteriole and venule branching complexity, both markers of impaired microvascular health. Computationally-derived PVS metrics may be an early indicator of failing vascular health and should be tested in longitudinal studies.
dc.description.confidentialfalse
dc.edition.edition2020
dc.format.extent? - ? (9)
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S2666245020300027
dc.identifier100002
dc.identifierS2666245020300027
dc.identifier.citationCerebral Circulation - Cognition and Behavior, 2020, 2020, 1 pp. ? - ? (9)
dc.identifier.doi10.1016/j.cccb.2020.100002
dc.identifier.elements-id435942
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2666-2450
dc.languageEnglish
dc.publisherElsevier BV
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S2666245020300027
dc.relation.isPartOfCerebral Circulation - Cognition and Behavior
dc.rightsCC BY 4.0
dc.subjectMRI
dc.subjectAgeing
dc.subjectPerivascular spaces
dc.subjectRetina
dc.titleQuantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Built Environment
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