Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals-Illustrated with Four Actin Cytoskeleton Proteins

Simple item page
dc.citation.issue3
dc.citation.volume9
dc.contributor.authorAkram Z
dc.contributor.authorAhmed I
dc.contributor.authorMack H
dc.contributor.authorKaur R
dc.contributor.authorSilva RC
dc.contributor.authorCastilho BA
dc.contributor.authorFriant S
dc.contributor.authorSattlegger E
dc.contributor.authorMunn AL
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-01-08T20:47:51Z
dc.date.accessioned2024-07-25T06:48:07Z
dc.date.available2020-03-10
dc.date.available2024-01-08T20:47:51Z
dc.date.available2024-07-25T06:48:07Z
dc.date.issued2020-03-10
dc.description.abstractThe budding yeast Saccharomyces cerevisiae has an actin cytoskeleton that comprises a set of protein components analogous to those found in the actin cytoskeletons of higher eukaryotes. Furthermore, the actin cytoskeletons of S. cerevisiae and of higher eukaryotes have some similar physiological roles. The genetic tractability of budding yeast and the availability of a stable haploid cell type facilitates the application of molecular genetic approaches to assign functions to the various actin cytoskeleton components. This has provided information that is in general complementary to that provided by studies of the equivalent proteins of higher eukaryotes and hence has enabled a more complete view of the role of these proteins. Several human functional homologues of yeast actin effectors are implicated in diseases. A better understanding of the molecular mechanisms underpinning the functions of these proteins is critical to develop improved therapeutic strategies. In this article we chose as examples four evolutionarily conserved proteins that associate with the actin cytoskeleton: 1) yeast Hof1p/mammalian PSTPIP1, 2) yeast Rvs167p/mammalian BIN1, 3) yeast eEF1A/eEF1A1 and eEF1A2 and 4) yeast Yih1p/mammalian IMPACT. We compare the knowledge on the functions of these actin cytoskeleton-associated proteins that has arisen from studies of their homologues in yeast with information that has been obtained from in vivo studies using live animals or in vitro studies using cultured animal cell lines.
dc.description.confidentialfalse
dc.edition.editionMarch 2020
dc.format.paginationE672-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32164332
dc.identifier.citationAkram Z, Ahmed I, Mack H, Kaur R, Silva RC, Castilho BA, Friant S, Sattlegger E, Munn AL. (2020). Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals-Illustrated with Four Actin Cytoskeleton Proteins.. Cells. 9. 3. (pp. E672-).
dc.identifier.doi10.3390/cells9030672
dc.identifier.eissn2073-4409
dc.identifier.elements-typejournal-article
dc.identifier.issn2073-4409
dc.identifier.numberARTN 672
dc.identifier.piicells9030672
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70910
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2073-4409/9/3/672
dc.relation.isPartOfCells
dc.rights(c) 2020 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBAR domain
dc.subjectF-BAR domain
dc.subjectMyc
dc.subjectWASP
dc.subjectWiskott-Aldrich Syndrome
dc.subjectcancer
dc.subjectcytokinesis
dc.subjectendocytosis
dc.subjecttranslation factors
dc.subjecttumor suppressor
dc.subjectActin Cytoskeleton
dc.subjectHumans
dc.subjectSaccharomyces cerevisiae
dc.subjectSaccharomyces cerevisiae Proteins
dc.subjectYeasts
dc.titleYeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals-Illustrated with Four Actin Cytoskeleton Proteins
dc.typeJournal article
pubs.elements-id431259
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
431259 PDF.pdf
Size:
1.78 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles