Immunostaining for VEGF and Decorin Predicts Poor Survival and Recurrence in Canine Soft Tissue Sarcoma.

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dc.citation.issue4
dc.citation.volume10
dc.contributor.authorBray JP
dc.contributor.authorPerrott MR
dc.contributor.authorMunday JS
dc.contributor.editorvan der Weyden L
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-08-15T21:34:01Z
dc.date.available2024-08-15T21:34:01Z
dc.date.issued2023-03-28
dc.description.abstractThe aim of this study was to investigate whether using immunohistochemistry to detect the angiogenic proteins vascular endothelial growth factor (VEGF) and decorin can help predict the risk of local recurrence of, or death from, canine soft tissue sarcoma (STS). VEGF and decorin were detected using validated immunohistochemical methods on 100 formalin-fixed paraffin-embedded samples of canine STS. The tumours had been resected previously, with clinical outcome determined by questionnaire. Each slide was assessed by light microscopy and the pattern of immunostaining with VEGF and decorin determined. Patterns of immunostaining were then analysed to detect associations with outcome measures of local recurrence and tumour-related death. High VEGF immunostaining was significantly (p < 0.001) associated with both increased local recurrence and reduced survival time. The distribution of decorin immunostaining within the tumour was significantly associated with survival time (p = 0.04) and local tumour recurrence (p = 0.02). When VEGF and decorin scores were combined, STS with both high VEGF and low decorin immunostaining were more likely to recur or cause patient death (p < 0.001). The results of this study suggest that immunostaining of VEGF and decorin may help predict the risk of local recurrence of canine STS.
dc.description.confidentialfalse
dc.edition.editionApril 2023
dc.format.pagination256-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37104411
dc.identifier.citationBray JP, Perrott MR, Munday JS. (2023). Immunostaining for VEGF and Decorin Predicts Poor Survival and Recurrence in Canine Soft Tissue Sarcoma.. Vet Sci. 10. 4. (pp. 256-).
dc.identifier.doi10.3390/vetsci10040256
dc.identifier.eissn2306-7381
dc.identifier.elements-typejournal-article
dc.identifier.issn2306-7381
dc.identifier.number256
dc.identifier.piivetsci10040256
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71320
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2306-7381/10/4/256
dc.relation.isPartOfVet Sci
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectVEGF
dc.subjectangiogenesis
dc.subjectcanine
dc.subjectdecorin
dc.subjectprognosis
dc.subjectsoft tissue sarcoma
dc.titleImmunostaining for VEGF and Decorin Predicts Poor Survival and Recurrence in Canine Soft Tissue Sarcoma.
dc.typeJournal article
pubs.elements-id461139
pubs.organisational-groupCollege of Health
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