Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis

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dc.citation.volume15
dc.contributor.authorBooth J
dc.contributor.authorConnelly L
dc.contributor.authorLawrence M
dc.contributor.authorChalmers C
dc.contributor.authorJoice S
dc.contributor.authorBecker C
dc.contributor.authorDougall N
dc.date.available2015-11-12
dc.date.available2015-10-02
dc.date.issued2015
dc.description.abstractAbstract Background : Several studies suggest that perceived psychosocial stress is associated with increased risk of stroke; however results are inconsistent with regard to definitions and measurement of perceived stress, features of individual study design, study conduct and conclusions drawn and no meta-analysis has yet been published. We performed a systematic review and meta-analysis of studies assessing association between perceived psychosocial stress and risk of stroke in adults.The results of the meta-analysis are presented. Methods: Systematic searches of MEDLINE, EMBASE, CINAHL, PsycInfo, and Cochrane Database of Systematic Reviews were undertaken between 1980 and June 2014. Data extraction and quality appraisal was performed by two independent reviewers. Hazard ratios (HR) and odds ratios (OR) were pooled where appropriate. Results: 14 studies were included in the meta-analysis, 10 prospective cohort, 4 case–control design. Overall pooled adjusted effect estimate for risk of total stroke in subjects exposed to general or work stress or to stressful life events was 1.33 (95 % confidence interval [CI], 1.17, 1.50; P < 0.00001). Sub-group analyses showed perceived psychosocial stress to be associated with increased risk of fatal stroke (HR 1.45 95 % CI, 1.19,1.78; P = 0.0002), total ischaemic stroke (HR 1.40 95 % CI, 1.00,1.97; P = 0.05) and total haemorrhagic stroke (HR 1.73 95 % CI, 1.33,2.25; P > 0.0001).A sex difference was noted with higher stroke risk identified for women (HR 1.90 95 % CI, 1.4, 2.56: P < 0.0001) compared to men (HR 1.24 95 % CI, 1.12, 1.36; P < 0.0001). Conclusions: Current evidence indicates that perceived psychosocial stress is independently associated with increased risk of stroke.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000365298200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN 233
dc.identifier.citationBMC NEUROLOGY, 2015, 15
dc.identifier.doi10.1186/s12883-015-0456-4
dc.identifier.elements-id284923
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1471-2377
dc.publisherBioMed Central
dc.relation.isPartOfBMC NEUROLOGY
dc.rights© 2015 Booth et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
dc.subjectStress
dc.subjectPsychological
dc.subjectStroke
dc.subjectRisk factor
dc.subject.anzsrc1109 Neurosciences
dc.subject.anzsrc1702 Cognitive Sciences
dc.titleEvidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Humanities and Social Sciences
pubs.organisational-group/Massey University/College of Humanities and Social Sciences/School of Psychology
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