Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds

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dc.citation.issue11
dc.citation.volume13
dc.contributor.authorNezbedova L
dc.contributor.authorMcGhie T
dc.contributor.authorChristensen M
dc.contributor.authorHeyes J
dc.contributor.authorNasef NA
dc.contributor.authorMehta S
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-12-04T00:40:30Z
dc.date.accessioned2024-07-25T06:36:26Z
dc.date.available2021-11-11
dc.date.available2023-12-04T00:40:30Z
dc.date.available2024-07-25T06:36:26Z
dc.date.issued2021-11
dc.description.abstractCancer is one of the leading causes of death globally. Epidemiological studies have strongly linked a diet high in fruits to a lower incidence of cancer. Furthermore, extensive research shows that secondary plant metabolites known as phytochemicals, which are commonly found in fruits, have onco-preventive and chemo-protective effects. Apple is a commonly consumed fruit worldwide that is available all year round and is a rich source of phytochemicals. In this review, we summarize the association of apple consumption with cancer incidence based on findings from epidemiological and cohort studies. We further provide a comprehensive review of the main phytochemical patterns observed in apples and their bioavailability after consumption. Finally, we report on the latest findings from in vitro and in vivo studies highlighting some of the key molecular mechanisms targeted by apple phytochemicals in relation to inhibiting multiple ‘hallmarks of cancer’ that are important in the progression of cancer.
dc.format.pagination4025-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34836282
dc.identifier.citationNezbedova L, McGhie T, Christensen M, Heyes J, Nasef NA, Mehta S. (2021). Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds.. Nutrients. 13. 11. (pp. 4025-).
dc.identifier.doi10.3390/nu13114025
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.issn2072-6643
dc.identifier.numberARTN 4025
dc.identifier.piinu13114025
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70525
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfNutrients
dc.rights(c) 2021 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectantioxidants
dc.subjectapple
dc.subjectcancer
dc.subjectchemoprevention
dc.subjectfruit
dc.subjectphenolics
dc.subjectphytochemicals
dc.subjecttriterpenoids
dc.subjectAntineoplastic Agents
dc.subjectAntioxidants
dc.subjectBiological Availability
dc.subjectChemoprevention
dc.subjectDiet
dc.subjectFruit
dc.subjectHumans
dc.subjectMalus
dc.subjectNeoplasms
dc.subjectPhenols
dc.subjectPhytochemicals
dc.subjectPlant Extracts
dc.subjectTriterpenes
dc.titleOnco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds
dc.typeJournal article
pubs.elements-id449604
pubs.organisational-groupOther
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