The effect and underlying mechanisms of titanium dioxide nanoparticles on glucose homeostasis: A literature review

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dc.contributor.authorMohammadparast V
dc.contributor.authorMallard BL
dc.date.available2022-03-18
dc.date.available2022-03-09
dc.date.issued2023-01
dc.descriptionCAUL read and publish agreement 2023
dc.description.abstractTitanium dioxide (TiO2 ) is used extensively as a white pigment in the food industry, personal care, and a variety of products of everyday use. Although TiO2 has been categorized as a bioinert material, recent evidence has demonstrated different toxicity profiles of TiO2 nanoparticles (NPs) and a potential health risk to humans. Studies indicated that titanium dioxide enters the systemic circulation and accumulates in the lungs, liver, kidneys, spleen, heart, and central nervous system and may cause oxidative stress and tissue damage in these vital organs. Recently, some studies have raised concerns about the possible detrimental effects of TiO2 NPs on glucose homeostasis. However, the findings should be interpreted with caution due to the methodological issues. This article aims to evaluate current evidence regarding the effects of TiO2 NPs on glucose homeostasis, including possible underlying mechanisms. Furthermore, the limitations of current studies are discussed, which may provide a comprehensive understanding and new perspectives for future studies in this field.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000770376800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationJOURNAL OF APPLIED TOXICOLOGY, 2022
dc.identifier.doi10.1002/jat.4318
dc.identifier.eissn1099-1263
dc.identifier.elements-id452393
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0260-437X
dc.publisherJohn Wiley and Sons Ltd
dc.relation.isPartOfJOURNAL OF APPLIED TOXICOLOGY
dc.relation.urihttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.4318
dc.rights(c) The Author/s
dc.subjectblood glucose homeostasis
dc.subjectinsulin resistance
dc.subjecttitanium dioxide nanoparticles
dc.subject.anzsrc1115 Pharmacology and Pharmaceutical Sciences
dc.titleThe effect and underlying mechanisms of titanium dioxide nanoparticles on glucose homeostasis: A literature review
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/School of Health Science
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