Comparison of True Ileal Amino Acid Digestibility between Adult Humans and Growing Pigs

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dc.citation.issue7
dc.citation.volume152
dc.contributor.authorHodgkinson SM
dc.contributor.authorStroebinger N
dc.contributor.authorvan der Wielen N
dc.contributor.authorMensink M
dc.contributor.authorMontoya C
dc.contributor.authorHendriks WH
dc.contributor.authorde Vries S
dc.contributor.authorStein HH
dc.contributor.authorMoughan PJ
dc.coverage.spatialUnited States
dc.date.accessioned2024-10-11T02:20:43Z
dc.date.available2024-10-11T02:20:43Z
dc.date.issued2022-07
dc.description.abstractBACKGROUND: It is not feasible to determine the true ileal amino acid (AA) digestibility of protein sources in humans on a routine basis, and the growing pig has been recommended as an animal model for this purpose but requires further validation. OBJECTIVES: To determine and compare true ileal AA digestibility between adult human ileostomates and growing cannulated pigs for a range of food proteins. METHODS: Seven protein sources (black beans, bread, collagen, pigeon peas, wheat bran, whey protein isolate, and zein) that spanned the range of digestibilities typically seen in foods were evaluated. Six female growing pigs received each of the protein sources, as well as a protein-free diet, and digesta were collected via ileal T-cannula. Adult human ileostomates consumed the same protein sources (5-8 ileostomates, depending on the protein source), as well as a protein-free diet, and digesta were collected. Titanium dioxide and celite were included in the diets as indigestible markers. True ileal AA digestibility coefficients were determined. RESULTS: There was a significant effect of protein source (P ≤ 0.001) for all AAs. The effect of species was not significant (P > 0.05) except for total lysine (but not for available lysine). When analyzed within diets, the statistically significant species effect for true lysine digestibility was found for black beans only. Pig and human digestibility values were generally highly and significantly (P ≤ 0.05) correlated. A linear regression equation derived for true ileal AA digestibility (given as coefficients) determined in the human and pig for the overall mean of all AAs was (y = human, x = pig) y = 1.00x - 0.010, with the slope not statistically significant (P > 0.05) from unity and the intercept not different (P > 0.05) from zero. CONCLUSIONS: True ileal AA digestibility values determined in the growing pig can be directly used for predicting digestibility in adult humans.
dc.description.confidentialfalse
dc.edition.editionJuly 2022
dc.format.pagination1635-1646
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35349701
dc.identifier.citationHodgkinson SM, Stroebinger N, van der Wielen N, Mensink M, Montoya C, Hendriks WH, de Vries S, Stein HH, Moughan PJ. (2022). Comparison of True Ileal Amino Acid Digestibility between Adult Humans and Growing Pigs.. J Nutr. 152. 7. (pp. 1635-1646).
dc.identifier.doi10.1093/jn/nxac077
dc.identifier.eissn1541-6100
dc.identifier.elements-typejournal-article
dc.identifier.issn0022-3166
dc.identifier.piiS0022-3166(22)00665-4
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71687
dc.languageeng
dc.publisherOxford University Press on behalf of the American Society for Nutrition
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0022316622006654
dc.relation.isPartOfJ Nutr
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDIAAS, protein quality
dc.subjectcannulated pig
dc.subjecthuman ileostomates
dc.subjecttrue ileal amino acid digestibility
dc.subjectAmino Acids
dc.subjectAnimal Feed
dc.subjectAnimal Nutritional Physiological Phenomena
dc.subjectAnimals
dc.subjectDiet
dc.subjectDigestion
dc.subjectFemale
dc.subjectHumans
dc.subjectIleum
dc.subjectLysine
dc.subjectSwine
dc.titleComparison of True Ileal Amino Acid Digestibility between Adult Humans and Growing Pigs
dc.typeJournal article
pubs.elements-id452644
pubs.organisational-groupOther
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