In vitro and in vivo studies on treatment and prevention of bovine mastitis : a thesis presented in partial fulfilment of the requirements for the degree of Philosophy Doctor in Veterinary Science at Massey University, Palmerston North, New Zealand

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dc.contributor.authorPetrovski, Kiro R.
dc.date.accessioned2012-02-06T22:36:00Z
dc.date.available2012-02-06T22:36:00Z
dc.date.issued2011
dc.descriptionContent removed due to copyright restrictions: ch. 3. Petrovski, K. R., Williamson, N. B., Lopez-Villalobos, N., Parkinson, T. J., & Tucker, I. G. (2011). Culture results from milk samples submitted to veterinary diagnostic laboratories from August 2003 to December 2006 in New Zealand. New Zealand Veterinary Journal, 59(6), 317-322. doi: 10.1080/00480169.2011.610286 ch. 4. Petrovski, K. R., Laven R. A., & Lopez-Villalobos N.(2011). A descriptive analysis of the antimicrobial susceptibility of mastitis-causing bacteria isolated from samples submitted to commercial diagnostic laboratories in New Zealand (2003-2006). New Zealand Veterinary Journal, 59(2), 59 - 66. doi:10.1080/00480169.2011.552853 ch. 13. Petrovski K. R., Caicedo-Caldas A, Williamson N. B., Lopez-Villalobos N., Grinberg A., Parkinson T. J., & Tucker I. G. (2011). Efficacy of a novel internal dry period teat sealant containing 0.5% chlorhexidine against experimental challenge with Streptococcus uberis in dairy cattle. Journal of Dairy Science, 94, 3366-75. doi: 10.3168/jds.2010-3744en_US
dc.description.abstractMastitis prevalence on dairy farms depends on the number of infected cows and the duration of each intramammary infection. Strategies aiming to influence these factors are the subject of research presented in this thesis. Decreasing the duration of infection can be achieved by successfully treating infected quarters. Treatment of mastitis can occur during lactation or in the dry period. Treatment success is influenced by the concentration of antimicrobial achieved at the site of infection and the length of time it is present. The concentration of antimicrobial should exceed the relevant minimal inhibitory concentration. The susceptibility of mastitis-causing organisms varies among geographical areas and over time. New Zealand’s susceptibility data demonstrated a high susceptibility to penicillin. A formulation containing this antimicrobial was administered to healthy lactating cows milked once or twice daily. The concentrations of penicillin in milk were above the minimal inhibitory concentrations for the entire inter-dosing interval. Doubling the number of treatments or milking once-a-day resulted in a significantly increased time above the minimal inhibitory concentrations. The number of new infections is greatest during the early dry period in mature cows and in the pre-calving period in both heifers and mature cows. Pre-partum administration of delayed release antimicrobial formulations in heifers decreased the incidence of clinical mastitis and resulted in better reproductive performance, but not in increased milk production, when compared to control heifers. More effective prevention of new infections within the dry period was achieved by administering a novel teat sealant to mature cows when compared to a commercial teat sealant and untreated controls. Strategies for shortening the duration of intramammary infections and decreasing the number of affected cows at the start of lactation investigated in this thesis should reduce the prevalence of mastitis on dairy farms in New Zealand.en_US
dc.identifier.urihttp://hdl.handle.net/10179/3074
dc.language.isoenen_US
dc.publisherMassey Universityen_US
dc.rightsThe Authoren_US
dc.subjectBovine mastitisen_US
dc.subjectAetiologyen_US
dc.subjectAntibioticsen_US
dc.subjectAntimicrobialsen_US
dc.subjectChallengeen_US
dc.subjectDry perioden_US
dc.subjectHeifersen_US
dc.subjectIndividual cow somatic cell counten_US
dc.subjectInternal teat sealanten_US
dc.subjectMilking frequencyen_US
dc.subjectPenicillinen_US
dc.subjectReproductive performanceen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectStreptococcus uberisen_US
dc.subjectStreptococcus dysgalactiaeen_US
dc.subjectSusceptibilityen_US
dc.subjectUdderen_US
dc.subjectNew Zealand
dc.titleIn vitro and in vivo studies on treatment and prevention of bovine mastitis : a thesis presented in partial fulfilment of the requirements for the degree of Philosophy Doctor in Veterinary Science at Massey University, Palmerston North, New Zealanden_US
dc.typeThesisen_US
massey.contributor.authorPetrovski, Kiro R.
thesis.degree.disciplineVeterinary Science
thesis.degree.grantorMassey University
thesis.degree.levelDoctoral
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophy (Ph.D.)
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