Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on quol production and bone mineral density in isoflavone-treated ovariectomised mice

Simple item page
dc.citation.volume1
dc.contributor.authorTousen Y
dc.contributor.authorUehara M
dc.contributor.authorKruger MC
dc.contributor.authorIshimi Y
dc.coverage.spatialEngland
dc.date.available2012
dc.date.available2012-08-08
dc.date.issued2012
dc.descriptionCreative Commons Attribution Non-Commercial Share Alike 2.5 License
dc.description.abstractEquol is a metabolite of the isoflavone daidzein (Dz) and is produced by the bacterial microflora in the distal intestine and colon. Some epidemiological studies have reported an association between increased equol production and intakes of green tea or dietary fibre, which are ingredients of the standard Japanese diet. We examined the effects of a diet supplemented with Dz and tea catechin or dietary fibre on equol production and bone mineral density in ovariectomised (OVX) mice. Female mice of the ddY strain were either sham operated or OVX. OVX mice were fed a control diet, a 0·1 % Dz-supplemented diet or a 0·1 % Dz diet supplemented with one of the food components commonly consumed in the Japanese diet. The mice were given 1 % tea catechin (w/w) as part of the diet in Expt 1 or 5 % polydextrose (PD) and 5 % raffinose (Raf) (w/w) as part of the diet in Expt 2. Catechin reduced serum equol levels and attenuated the beneficial effect of Dz on femoral bone loss. The soluble dietary fibres PD and Raf stimulated equol production, and enhanced the bone-protective effects of Dz on femoral bone. These results suggest that dietary fibre, in particular, PD, may alter the bioavailability of isoflavones and prevent osteopenia in OVX mice.
dc.description.publication-statusPublished online
dc.format.extente13 - ?
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/25191542
dc.identifier00014
dc.identifier.citationJ Nutr Sci, 2012, 1 pp. e13 - ?
dc.identifier.doi10.1017/jns.2012.14
dc.identifier.elements-id184029
dc.identifier.issn2048-6790
dc.languageeng
dc.publisherCambridge University Press
dc.relation.isPartOfJ Nutr Sci
dc.subjectBMD, bone mineral density
dc.subjectDietary fibre
dc.subjectDz, daidzein
dc.subjectEGCG, epigallocatechin gallate
dc.subjectEquol
dc.subjectJapanese diet
dc.subjectOVX, ovariectomised
dc.subjectPD, polydextrose
dc.subjectRaf, raffinose
dc.subjectSoya isoflavones
dc.subject.anzsrc1111 Nutrition and Dietetics
dc.titleEffects of dietary fibre and tea catechin, ingredients of the Japanese diet, on quol production and bone mineral density in isoflavone-treated ovariectomised mice
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/School of Health Science
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Effects of dietary fibre and tea catechin..pdf
Size:
787.76 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles