Increasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis

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dc.citation.volume10
dc.contributor.authorCarco C
dc.contributor.authorYoung W
dc.contributor.authorGearry RB
dc.contributor.authorTalley NJ
dc.contributor.authorMcNabb WC
dc.contributor.authorRoy NC
dc.contributor.editorIaniro G
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-18T01:51:20Z
dc.date.available2024-10-18T01:51:20Z
dc.date.issued2020-09-09
dc.description.abstractThe human gastrointestinal tract harbors most of the microbial cells inhabiting the body, collectively known as the microbiota. These microbes have several implications for the maintenance of structural integrity of the gastrointestinal mucosal barrier, immunomodulation, metabolism of nutrients, and protection against pathogens. Dysfunctions in these mechanisms are linked to a range of conditions in the gastrointestinal tract, including functional gastrointestinal disorders, ranging from irritable bowel syndrome, to functional constipation and functional diarrhea. Irritable bowel syndrome is characterized by chronic abdominal pain with changes in bowel habit in the absence of morphological changes. Despite the high prevalence of irritable bowel syndrome in the global population, the mechanisms responsible for this condition are poorly understood. Although alterations in the gastrointestinal microbiota, low-grade inflammation and immune activation have been implicated in the pathophysiology of functional gastrointestinal disorders, there is inconsistency between studies and a lack of consensus on what the exact role of the microbiota is, and how changes to it relate to these conditions. The complex interplay between host factors, such as microbial dysbiosis, immune activation, impaired epithelial barrier function and motility, and environmental factors, including diet, will be considered in this narrative review of the pathophysiology of functional gastrointestinal disorders.
dc.description.confidentialfalse
dc.format.pagination468-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33014892
dc.identifier.citationCarco C, Young W, Gearry RB, Talley NJ, McNabb WC, Roy NC. (2020). Increasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis.. Front Cell Infect Microbiol. 10. (pp. 468-).
dc.identifier.doi10.3389/fcimb.2020.00468
dc.identifier.eissn2235-2988
dc.identifier.elements-typejournal-article
dc.identifier.issn2235-2988
dc.identifier.numberARTN 468
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71763
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.00468/full
dc.relation.isPartOfFront Cell Infect Microbiol
dc.rights(c) 2020 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdiet
dc.subjectfunctional gastrointestinal disorders
dc.subjecthost-microbe interactions
dc.subjecthuman microbiota
dc.subjectimmunity
dc.subjectirritable bowel syndrome
dc.subjectmotility
dc.subjectvisceral pain
dc.subjectDysbiosis
dc.subjectGastrointestinal Diseases
dc.subjectGastrointestinal Microbiome
dc.subjectHumans
dc.subjectIrritable Bowel Syndrome
dc.titleIncreasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis
dc.typeJournal article
pubs.elements-id434977
pubs.organisational-groupOther
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