Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.

Simple item page
dc.citation.issue1
dc.citation.volume14
dc.contributor.authorThomas M
dc.contributor.authorSu Y-R
dc.contributor.authorRosenthal EA
dc.contributor.authorSakoda LC
dc.contributor.authorSchmit SL
dc.contributor.authorTimofeeva MN
dc.contributor.authorChen Z
dc.contributor.authorFernandez-Rozadilla C
dc.contributor.authorLaw PJ
dc.contributor.authorMurphy N
dc.contributor.authorCarreras-Torres R
dc.contributor.authorDiez-Obrero V
dc.contributor.authorvan Duijnhoven FJB
dc.contributor.authorJiang S
dc.contributor.authorShin A
dc.contributor.authorWolk A
dc.contributor.authorPhipps AI
dc.contributor.authorBurnett-Hartman A
dc.contributor.authorGsur A
dc.contributor.authorChan AT
dc.contributor.authorZauber AG
dc.contributor.authorWu AH
dc.contributor.authorLindblom A
dc.contributor.authorUm CY
dc.contributor.authorTangen CM
dc.contributor.authorGignoux C
dc.contributor.authorNewton C
dc.contributor.authorHaiman CA
dc.contributor.authorQu C
dc.contributor.authorBishop DT
dc.contributor.authorBuchanan DD
dc.contributor.authorCrosslin DR
dc.contributor.authorConti DV
dc.contributor.authorKim D-H
dc.contributor.authorHauser E
dc.contributor.authorWhite E
dc.contributor.authorSiegel E
dc.contributor.authorSchumacher FR
dc.contributor.authorRennert G
dc.contributor.authorGiles GG
dc.contributor.authorHampel H
dc.contributor.authorBrenner H
dc.contributor.authorOze I
dc.contributor.authorOh JH
dc.contributor.authorLee JK
dc.contributor.authorSchneider JL
dc.contributor.authorChang-Claude J
dc.contributor.authorKim J
dc.contributor.authorHuyghe JR
dc.contributor.authorZheng J
dc.contributor.authorHampe J
dc.contributor.authorGreenson J
dc.contributor.authorHopper JL
dc.contributor.authorPalmer JR
dc.contributor.authorVisvanathan K
dc.contributor.authorMatsuo K
dc.contributor.authorMatsuda K
dc.contributor.authorJung KJ
dc.contributor.authorLi L
dc.contributor.authorLe Marchand L
dc.contributor.authorVodickova L
dc.contributor.authorBujanda L
dc.contributor.authorGunter MJ
dc.contributor.authorMatejcic M
dc.contributor.authorJenkins MA
dc.contributor.authorSlattery ML
dc.contributor.authorD'Amato M
dc.contributor.authorWang M
dc.contributor.authorHoffmeister M
dc.contributor.authorWoods MO
dc.contributor.authorKim M
dc.contributor.authorSong M
dc.contributor.authorIwasaki M
dc.contributor.authorDu M
dc.contributor.authorUdaltsova N
dc.contributor.authorSawada N
dc.contributor.authorVodicka P
dc.contributor.authorCampbell PT
dc.contributor.authorNewcomb PA
dc.contributor.authorCai Q
dc.contributor.authorPearlman R
dc.contributor.authorPai RK
dc.contributor.authorSchoen RE
dc.contributor.authorSteinfelder RS
dc.contributor.authorHaile RW
dc.contributor.authorVandenputtelaar R
dc.contributor.authorPrentice RL
dc.contributor.authorKüry S
dc.contributor.authorCastellví-Bel S
dc.contributor.authorTsugane S
dc.contributor.authorBerndt SI
dc.contributor.authorLee SC
dc.contributor.authorBrezina S
dc.contributor.authorWeinstein SJ
dc.contributor.authorChanock SJ
dc.contributor.authorJee SH
dc.contributor.authorKweon S-S
dc.contributor.authorVadaparampil S
dc.contributor.authorHarrison TA
dc.contributor.authorYamaji T
dc.contributor.authorKeku TO
dc.contributor.authorVymetalkova V
dc.contributor.authorArndt V
dc.contributor.authorJia W-H
dc.contributor.authorShu X-O
dc.contributor.authorLin Y
dc.contributor.authorAhn Y-O
dc.contributor.authorStadler ZK
dc.contributor.authorVan Guelpen B
dc.contributor.authorUlrich CM
dc.contributor.authorPlatz EA
dc.contributor.authorPotter JD
dc.contributor.authorLi CI
dc.contributor.authorMeester R
dc.contributor.authorMoreno V
dc.contributor.authorFigueiredo JC
dc.contributor.authorCasey G
dc.contributor.authorLansdorp Vogelaar I
dc.contributor.authorDunlop MG
dc.contributor.authorGruber SB
dc.contributor.authorHayes RB
dc.contributor.authorPharoah PDP
dc.contributor.authorHoulston RS
dc.contributor.authorJarvik GP
dc.contributor.authorTomlinson IP
dc.contributor.authorZheng W
dc.contributor.authorCorley DA
dc.contributor.authorPeters U
dc.contributor.authorHsu L
dc.coverage.spatialEngland
dc.date.accessioned2024-08-27T21:35:35Z
dc.date.available2024-08-27T21:35:35Z
dc.date.issued2023-10-02
dc.description.abstractPolygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
dc.description.confidentialfalse
dc.format.pagination6147-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37783704
dc.identifier.citationThomas M, Su Y-R, Rosenthal EA, Sakoda LC, Schmit SL, Timofeeva MN, Chen Z, Fernandez-Rozadilla C, Law PJ, Murphy N, Carreras-Torres R, Diez-Obrero V, van Duijnhoven FJB, Jiang S, Shin A, Wolk A, Phipps AI, Burnett-Hartman A, Gsur A, Chan AT, Zauber AG, Wu AH, Lindblom A, Um CY, Tangen CM, Gignoux C, Newton C, Haiman CA, Qu C, Bishop DT, Buchanan DD, Crosslin DR, Conti DV, Kim D-H, Hauser E, White E, Siegel E, Schumacher FR, Rennert G, Giles GG, Hampel H, Brenner H, Oze I, Oh JH, Lee JK, Schneider JL, Chang-Claude J, Kim J, Huyghe JR, Zheng J, Hampe J, Greenson J, Hopper JL, Palmer JR, Visvanathan K, Matsuo K, Matsuda K, Jung KJ, Li L, Le Marchand L, Vodickova L, Bujanda L, Gunter MJ, Matejcic M, Jenkins MA, Slattery ML, D'Amato M, Wang M, Hoffmeister M, Woods MO, Kim M, Song M, Iwasaki M, Du M, Udaltsova N, Sawada N, Vodicka P, Campbell PT, Newcomb PA, Cai Q, Pearlman R, Pai RK, Schoen RE, Steinfelder RS, Haile RW, Vandenputtelaar R, Prentice RL, Küry S, Castellví-Bel S, Tsugane S, Berndt SI, Lee SC, Brezina S, Weinstein SJ, Chanock SJ, Jee SH, Kweon S-S, Vadaparampil S, Harrison TA, Yamaji T, Keku TO, Vymetalkova V, Arndt V, Jia W-H, Shu X-O, Lin Y, Ahn Y-O, Stadler ZK, Van Guelpen B, Ulrich CM, Platz EA, Potter JD, Li CI, Meester R, Moreno V, Figueiredo JC, Casey G, Lansdorp Vogelaar I, Dunlop MG, Gruber SB, Hayes RB, Pharoah PDP, Houlston RS, Jarvik GP, Tomlinson IP, Zheng W, Corley DA, Peters U, Hsu L. (2023). Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.. Nat Commun. 14. 1. (pp. 6147-).
dc.identifier.doi10.1038/s41467-023-41819-0
dc.identifier.eissn2041-1723
dc.identifier.elements-typejournal-article
dc.identifier.issn2041-1723
dc.identifier.number6147
dc.identifier.pii10.1038/s41467-023-41819-0
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71389
dc.languageeng
dc.publisherSpringer Nature
dc.publisher.urihttps://www.nature.com/articles/s41467-023-41819-0
dc.relation.isPartOfNat Commun
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectEthnicity
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Predisposition to Disease
dc.subjectPolymorphism, Single Nucleotide
dc.subjectRisk Factors
dc.subjectMultifactorial Inheritance
dc.subjectColorectal Neoplasms
dc.titleCombining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.
dc.typeJournal article
pubs.elements-id480859
pubs.organisational-groupCollege of Health
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