Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains

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dc.citation.volume9
dc.contributor.authorStanton J-AL
dc.contributor.authorO'Brien R
dc.contributor.authorHall RJ
dc.contributor.authorChernyavtseva A
dc.contributor.authorHa HJ
dc.contributor.authorJelley L
dc.contributor.authorMace PD
dc.contributor.authorKlenov A
dc.contributor.authorTreece JM
dc.contributor.authorFraser JD
dc.contributor.authorClow F
dc.contributor.authorClarke L
dc.contributor.authorSu Y
dc.contributor.authorKurup HM
dc.contributor.authorFilichev VV
dc.contributor.authorRolleston W
dc.contributor.authorLaw L
dc.contributor.authorRendle PM
dc.contributor.authorHarris LD
dc.contributor.authorWood JM
dc.contributor.authorScully TW
dc.contributor.authorUssher JE
dc.contributor.authorGrant J
dc.contributor.authorHore TA
dc.contributor.authorMoser TV
dc.contributor.authorHarfoot R
dc.contributor.authorLawley B
dc.contributor.authorQuiƱones-Mateu ME
dc.contributor.authorCollins P
dc.contributor.authorBlaikie R
dc.contributor.editorSĆørensen JL
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-12-07T18:43:22Z
dc.date.accessioned2024-07-25T06:53:39Z
dc.date.available2022-01-24
dc.date.available2023-12-07T18:43:22Z
dc.date.available2024-07-25T06:53:39Z
dc.date.issued2022-01-24
dc.description.abstractThe rapid global rise of COVID-19 from late 2019 caught major manufacturers of RT-qPCR reagents by surprise and threw into sharp focus the heavy reliance of molecular diagnostic providers on a handful of reagent suppliers. In addition, lockdown and transport bans, necessarily imposed to contain disease spread, put pressure on global supply lines with freight volumes severely restricted. These issues were acutely felt in New Zealand, an island nation located at the end of most supply lines. This led New Zealand scientists to pose the hypothetical question: in a doomsday scenario where access to COVID-19 RT-qPCR reagents became unavailable, would New Zealand possess the expertise and infrastructure to make its own reagents onshore? In this work we describe a review of New Zealand's COVID-19 test requirements, bring together local experts and resources to make all reagents for the RT-qPCR process, and create a COVID-19 diagnostic assay referred to as HomeBrew (HB) RT-qPCR from onshore synthesized components. This one-step RT-qPCR assay was evaluated using clinical samples and shown to be comparable to a commercial COVID-19 assay. Through this work we show New Zealand has both the expertise and, with sufficient lead time and forward planning, infrastructure capacity to meet reagent supply challenges if they were ever to emerge.
dc.description.confidentialfalse
dc.format.pagination808751-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35141190
dc.identifier.citationStanton J-AL, O'Brien R, Hall RJ, Chernyavtseva A, Ha HJ, Jelley L, Mace PD, Klenov A, Treece JM, Fraser JD, Clow F, Clarke L, Su Y, Kurup HM, Filichev VV, Rolleston W, Law L, Rendle PM, Harris LD, Wood JM, Scully TW, Ussher JE, Grant J, Hore TA, Moser TV, Harfoot R, Lawley B, QuiƱones-Mateu ME, Collins P, Blaikie R. (2021). Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains.. Front Public Health. 9. (pp. 808751-).
dc.identifier.doi10.3389/fpubh.2021.808751
dc.identifier.eissn2296-2565
dc.identifier.elements-typejournal-article
dc.identifier.issn2296-2565
dc.identifier.numberARTN 808751
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71112
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/articles/10.3389/fpubh.2021.808751/full
dc.relation.isPartOfFront Public Health
dc.rights(c) 2022 The Author/s
dc.rightsCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19
dc.subjectHomeBrew
dc.subjectRT-qPCR
dc.subjectmolecular reagents
dc.subjectsupply chain
dc.subjectCOVID-19
dc.subjectCOVID-19 Nucleic Acid Testing
dc.subjectHumans
dc.subjectIndicators and Reagents
dc.subjectSARS-CoV-2
dc.titleUncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains
dc.typeJournal article
pubs.elements-id451203
pubs.organisational-groupOther
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