Does parity matter in women’s risk of dementia? A COSMIC collaboration cohort study

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dc.citation.issue1
dc.citation.volume18
dc.contributor.authorBae JB
dc.contributor.authorLipnicki DM
dc.contributor.authorHan JW
dc.contributor.authorSachdev PS
dc.contributor.authorKim TH
dc.contributor.authorKwak KP
dc.contributor.authorKim BJ
dc.contributor.authorKim SG
dc.contributor.authorKim JL
dc.contributor.authorMoon SW
dc.contributor.authorPark JH
dc.contributor.authorRyu S-H
dc.contributor.authorYoun JC
dc.contributor.authorLee DY
dc.contributor.authorLee DW
dc.contributor.authorLee SB
dc.contributor.authorLee JJ
dc.contributor.authorJhoo JH
dc.contributor.authorLlibre-Rodriguez JJ
dc.contributor.authorLlibre-Guerra JJ
dc.contributor.authorValhuerdi-Cepero AJ
dc.contributor.authorRitchie K
dc.contributor.authorAncelin M-L
dc.contributor.authorCarriere I
dc.contributor.authorSkoog I
dc.contributor.authorNajar J
dc.contributor.authorSterner TR
dc.contributor.authorScarmeas N
dc.contributor.authorYannakoulia M
dc.contributor.authorDardiotis E
dc.contributor.authorMeguro K
dc.contributor.authorKasai M
dc.contributor.authorNakamura K
dc.contributor.authorRiedel-Heller S
dc.contributor.authorRoehr S
dc.contributor.authorPabst A
dc.contributor.authorvan Boxtel M
dc.contributor.authorKöhler S
dc.contributor.authorDing D
dc.contributor.authorZhao Q
dc.contributor.authorLiang X
dc.contributor.authorScazufca M
dc.contributor.authorLobo A
dc.contributor.authorDe-la-Cámara C
dc.contributor.authorLobo E
dc.contributor.authorKim KW
dc.contributor.authorfor Cohort Studies of Memory in an International Consortium (COSMIC)
dc.coverage.spatialEngland
dc.date.accessioned2023-11-22T01:33:54Z
dc.date.accessioned2024-07-25T06:32:52Z
dc.date.available2020-08-05
dc.date.available2023-11-22T01:33:54Z
dc.date.available2024-07-25T06:32:52Z
dc.date.issued2020-08-05
dc.description.abstractBackground Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied. Methods We harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14,792 women aged 60 years or older. We investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype. Results Across all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.10–1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. However, there were differences associated with region and dementia subtype. Compared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in Europe (OR = 2.99, 95% CI = 1.38–6.47) and Latin America (OR = 1.49, 95% CI = 1.04–2.12), while nulliparous women showed a higher dementia risk in Asia (OR = 2.15, 95% CI = 1.33–3.47). Grand multiparity was associated with 6.9-fold higher risk of vascular dementia in Europe (OR = 6.86, 95% CI = 1.81–26.08), whereas nulliparity was associated with a higher risk of Alzheimer disease (OR = 1.91, 95% CI 1.07–3.39) and non-Alzheimer non-vascular dementia (OR = 3.47, 95% CI = 1.44–8.35) in Asia. Conclusion Parity is associated with women’s risk of dementia, though this is not uniform across regions and dementia subtypes.
dc.format.pagination210-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32753059
dc.identifier.citationBae JB, Lipnicki DM, Han JW, Sachdev PS, Kim TH, Kwak KP, Kim BJ, Kim SG, Kim JL, Moon SW, Park JH, Ryu S-H, Youn JC, Lee DY, Lee DW, Lee SB, Lee JJ, Jhoo JH, Llibre-Rodriguez JJ, Llibre-Guerra JJ, Valhuerdi-Cepero AJ, Ritchie K, Ancelin M-L, Carriere I, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Dardiotis E, Meguro K, Kasai M, Nakamura K, Riedel-Heller S, Roehr S, Pabst A, van Boxtel M, Köhler S, Ding D, Zhao Q, Liang X, Scazufca M, Lobo A, De-la-Cámara C, Lobo E, Kim KW, for Cohort Studies of Memory in an International Consortium (COSMIC) . (2020). Does parity matter in women's risk of dementia? A COSMIC collaboration cohort study.. BMC Med. 18. 1. (pp. 210-).
dc.identifier.doi10.1186/s12916-020-01671-1
dc.identifier.eissn1741-7015
dc.identifier.elements-typejournal-article
dc.identifier.issn1741-7015
dc.identifier.pii10.1186/s12916-020-01671-1
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70390
dc.languageeng
dc.publisherBMC
dc.relation.isPartOfBMC Med
dc.rights(c) 2020 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer’s disease
dc.subjectDementia
dc.subjectParity
dc.subjectRisk factors
dc.subjectWomen
dc.subjectCohort Studies
dc.subjectDementia
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectParity
dc.subjectRisk Factors
dc.titleDoes parity matter in women’s risk of dementia? A COSMIC collaboration cohort study
dc.typeJournal article
pubs.elements-id455007
pubs.organisational-groupOther
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