Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes

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dc.citation.volume18
dc.contributor.authorMarks ECA
dc.contributor.authorWilkinson TM
dc.contributor.authorFrampton CM
dc.contributor.authorSkelton L
dc.contributor.authorPilbrow AP
dc.contributor.authorYandle TG
dc.contributor.authorPemberton CJ
dc.contributor.authorDoughty RN
dc.contributor.authorWhalley GA
dc.contributor.authorEllis CJ
dc.contributor.authorTroughton RW
dc.contributor.authorOwen MC
dc.contributor.authorPattinson NR
dc.contributor.authorCameron VA
dc.contributor.authorRichards AM
dc.contributor.authorGieseg SP
dc.contributor.authorPalmer BR
dc.date.available2018-08-15
dc.date.available2018-07-23
dc.date.issued15/08/2018
dc.description.abstractBACKGROUND: Development of collateral circulation in coronary artery disease is cardio-protective. A key process in forming new blood vessels is attraction to occluded arteries of monocytes with their subsequent activation as macrophages. In patients from a prospectively recruited post-acute coronary syndromes cohort we investigated the prognostic performance of three products of activated macrophages, soluble vascular endothelial growth factor (VEGF) receptors (sFlt-1 and sKDR) and pterins, alongside genetic variants in VEGF receptor genes, VEGFR-1 and VEGFR-2. METHODS: Baseline levels of sFlt-1 (VEGFR1), sKDR (VEGFR2) and pterins were measured in plasma samples from subgroups (n = 513; 211; 144, respectively) of the Coronary Disease Cohort Study (CDCS, n = 2067). DNA samples from the cohort were genotyped for polymorphisms from the VEGFR-1 gene SNPs (rs748252 n = 2027, rs9513070 n = 2048) and VEGFR-2 gene SNPs (rs2071559 n = 2050, rs2305948 n = 2066, rs1870377 n = 2042). RESULTS: At baseline, levels of sFlt-1 were significantly correlated with age, alcohol consumption, NTproBNP, BNP and other covariates relevant to cardiovascular pathophysiology. Total neopterin levels were associated with alcohol consumption at baseline. 7,8 dihydroneopterin was associated with BMI. The A allele of VEGFR-2 variant rs1870377 was associated with higher plasma sFlt-1 and lower levels of sKDR at baseline. Baseline plasma sFlt-1 was univariately associated with all cause mortality with (p < 0.001) and in a Cox's proportional hazards regression model sFlt-1 and pterins were both associated with mortality independent of established predictors (p < 0.027). CONCLUSIONS: sFlt-1 and pterins may have potential as prognostic biomarkers in acute coronary syndromes patients. Genetic markers from VEGF system genes warrant further investigation as markers of levels of VEGF system components in these patients. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry. ACTRN12605000431628 . 16 September 2005, Retrospectively registered.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000441496300002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN 169
dc.identifier.citationBMC CARDIOVASCULAR DISORDERS, 2018, 18
dc.identifier.doi10.1186/s12872-018-0894-1
dc.identifier.elements-id413509
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1471-2261
dc.identifier.urihttps://hdl.handle.net/10179/16039
dc.publisherBioMed Central Ltd
dc.relation.isPartOfBMC CARDIOVASCULAR DISORDERS
dc.subjectsFlt-1
dc.subjectKDR
dc.subjectNeopterin
dc.subjectAcute coronary syndromes
dc.subjectMortality
dc.subjectPrognosis
dc.subject.anzsrc1102 Cardiorespiratory Medicine and Haematology
dc.titlePlasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/School of Health Science
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