Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.

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dc.citation.issue11
dc.citation.volume19
dc.contributor.authorMahalingam G
dc.contributor.authorSamtani S
dc.contributor.authorLam BCP
dc.contributor.authorLipnicki DM
dc.contributor.authorLima-Costa MF
dc.contributor.authorBlay SL
dc.contributor.authorCastro-Costa E
dc.contributor.authorShifu X
dc.contributor.authorGuerchet M
dc.contributor.authorPreux P-M
dc.contributor.authorGbessemehlan A
dc.contributor.authorSkoog I
dc.contributor.authorNajar J
dc.contributor.authorSterner TR
dc.contributor.authorScarmeas N
dc.contributor.authorYannakoulia M
dc.contributor.authorDardiotis T
dc.contributor.authorKim K-W
dc.contributor.authorRiedel-Heller S
dc.contributor.authorRöhr S
dc.contributor.authorPabst A
dc.contributor.authorShahar S
dc.contributor.authorNumbers K
dc.contributor.authorGanguli M
dc.contributor.authorHughes TF
dc.contributor.authorChang C-CH
dc.contributor.authorCrowe M
dc.contributor.authorNg TP
dc.contributor.authorGwee X
dc.contributor.authorChua DQL
dc.contributor.authorRymaszewska J
dc.contributor.authorWolf-Ostermann K
dc.contributor.authorWelmer A-K
dc.contributor.authorStafford J
dc.contributor.authorMélis R
dc.contributor.authorVernooij-Dassen M
dc.contributor.authorJeon Y-H
dc.contributor.authorSachdev PS
dc.contributor.authorBrodaty H
dc.contributor.authorSHARED consortium for the Cohort Studies of Memory in an International Consortium (COSMIC)
dc.coverage.spatialUnited States
dc.date.accessioned2024-05-17T03:13:12Z
dc.date.available2024-05-17T03:13:12Z
dc.date.issued2023-11
dc.description.abstractINTRODUCTION: Previous meta-analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection markers. METHODS: We used individual participant data (N = 39271, Mage  = 70.67 (40-102), 58.86% female, Meducation  = 8.43 years, Mfollow-up  = 3.22 years) from 13 longitudinal ageing studies. A two-stage meta-analysis of Cox regression models examined the association between social connection markers with our primary outcomes. RESULTS: We found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment (MCI); between social structure and function and lower risk of incident dementia and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality. DISCUSSION: Different aspects of social connections - structure, function, and quality - are associated with benefits for healthy aging internationally. HIGHLIGHTS: Social connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident MCI. Social connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia. Social connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality. Evidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident MCI, incident dementia, and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality. Highlights Social connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident MCI. Social connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia. Social connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality. Evidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident MCI, incident dementia, and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.
dc.description.confidentialfalse
dc.edition.editionNovember 2023
dc.format.pagination5114-5128
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37102417
dc.identifier.citationMahalingam G, Samtani S, Lam BCP, Lipnicki DM, Lima-Costa MF, Blay SL, Castro-Costa E, Shifu X, Guerchet M, Preux P-M, Gbessemehlan A, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Dardiotis T, Kim K-W, Riedel-Heller S, Röhr S, Pabst A, Shahar S, Numbers K, Ganguli M, Hughes TF, Chang C-CH, Crowe M, Ng TP, Gwee X, Chua DQL, Rymaszewska J, Wolf-Ostermann K, Welmer A-K, Stafford J, Mélis R, Vernooij-Dassen M, Jeon Y-H, Sachdev PS, Brodaty H, SHARED consortium for the Cohort Studies of Memory in an International Consortium (COSMIC) . (2023). Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.. Alzheimers Dement. 19. 11. (pp. 5114-5128).
dc.identifier.doi10.1002/alz.13072
dc.identifier.eissn1552-5279
dc.identifier.elements-typejournal-article
dc.identifier.issn1552-5260
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69593
dc.languageeng
dc.publisherWiley Periodicals LLC on behalf of Alzheimer’s Association.
dc.publisher.urihttps://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13072
dc.relation.isPartOfAlzheimers Dement
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdementia
dc.subjectlongitudinal
dc.subjectmeta-analysis
dc.subjectmild cognitive impairment
dc.subjectmortality
dc.subjectsocial connections
dc.subjectHumans
dc.subjectFemale
dc.subjectAged
dc.subjectMale
dc.subjectLongitudinal Studies
dc.subjectDementia
dc.subjectCohort Studies
dc.subjectCognitive Dysfunction
dc.subjectAging
dc.titleSocial connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.
dc.typeJournal article
pubs.elements-id461338
pubs.organisational-groupOther
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