Toxicity and pharmacokinetic studies of lidocaine and its active metabolite, monoethylglycinexylidide, in goat kids

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dc.citation.issue8
dc.citation.volume8
dc.contributor.authorVenkatachalam D
dc.contributor.authorChambers P
dc.contributor.authorKongara K
dc.contributor.authorSingh P
dc.date.available2018-08
dc.date.available2018-08-18
dc.date.issued2018-08
dc.description.abstractThis study determined the convulsant plasma concentrations and pharmacokinetic parameters following cornual nerve block and compared the results to recommend a safe dose of lidocaine hydrochloride for goat kids. The plasma concentrations of lidocaine and monoethylglycinexylidide (MGX) were quantified using liquid chromatography-mass spectrometry. A total dose of 7 mg/kg body weight (BW) was tolerated and should therefore be safe for local and regional anesthesia in goat kids. The mean plasma concentration and mean total dose that produced convulsions in goat kids were 13.59 ± 2.34 µg/mL and 12.31 ± 1.42 mg/kg BW (mean ± S.D.), respectively. The absorption of lidocaine following subcutaneous administration was rapid with Cmax and Tmax of 2.12 ± 0.81 µg/mL and 0.33 ± 0.11 h, respectively. The elimination half-lives (t½λz) of lidocaine hydrochloride and MGX were 1.71 ± 0.51 h and 3.19 ± 1.21 h, respectively. Injection of 1% lidocaine hydrochloride (0.5 mL/site) was safe and effective in blocking the nerves supplying horn buds in goat kids.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000443245700015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN 142
dc.identifier.citationANIMALS, 2018, 8 (8)
dc.identifier.doi10.3390/ani8080142
dc.identifier.elements-id413520
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2076-2615
dc.publisherMDPI
dc.relation.isPartOfANIMALS
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
dc.subjectdisbudding
dc.subjectgoat kids
dc.subjectlidocaine hydrochloride
dc.subjecttoxicity
dc.subjectpharmacokinetics
dc.subject.anzsrc0502 Environmental Science and Management
dc.subject.anzsrc0608 Zoology
dc.subject.anzsrc0702 Animal Production
dc.titleToxicity and pharmacokinetic studies of lidocaine and its active metabolite, monoethylglycinexylidide, in goat kids
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
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