The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress
Loading...
Date
2021-03-31
Open Access Location
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI (Basel, Switzerland)
Rights
(c) 2021 The Author/s
CC BY
CC BY
Abstract
Episodes of depression and anxiety commonly follow the experience of stress, however not everyone who experiences stress develops a mood disorder. Individuals who are able to experience stress without a negative emotional effect are considered stress resilient. Stress-resilience (and its counterpart stress-susceptibility) are influenced by several psychological and biological factors, including the microbiome-gut-brain axis. Emerging research shows that the gut microbiota can influence mood, and that stress is an important variable in this relationship. Stress alters the gut microbiota and plausibly this could contribute to stress-related changes in mood. Most of the reported research has been conducted using animal models and demonstrates a relationship between gut microbiome and mood. The translational evidence from human clinical studies however is rather limited. In this review we examine the microbiome-gut-brain axis research in relation to stress resilience.
Description
Keywords
anxiety, depression, enteric nervous system, gut microbiota, gut-inflammation, gut-permeability, mood, probiotics, stress, vagus nerve
Citation
Bear T, Dalziel J, Coad J, Roy N, Butts C, Gopal P. (2021). The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress.. Microorganisms. 9. 4. (pp. 723-).