The effect of age on the induction dose of propofol for general anesthesia in dogs

Simple item page
dc.citation.issue7 July
dc.citation.volume18
dc.contributor.authorHampton CE
dc.contributor.authorda Cunha A
dc.contributor.authorDesselle A
dc.contributor.authorQueiroz-Williams P
dc.contributor.authorHofmeister EH
dc.contributor.editorViegas CAA
dc.date.accessioned2025-10-21T20:47:52Z
dc.date.available2025-10-21T20:47:52Z
dc.date.issued2023-07-03
dc.description.abstractObjective In people, the dose of propofol (DOP) required for procedural sedation and anesthesia decreases significantly with age. The objective of this study was to determine if the DOP required to perform endotracheal intubation decreases with age in dogs. Study design Retrospective case series. Animals 1397 dogs. Methods Data from dogs anesthetized at referral center (2017–2020) were analyzed with three multivariate linear regression models with backward elimination using a combination of either absolute age, physiologic age, or life expectancy (ratio between age at the time of anesthetic event and expected age of death for each breed obtained from previous literature) as well as other factors as independent variables, and DOP as the dependent variable. The DOP for each quartile of life expectancy (<25%, 25–50%, 50–75%, 75–100%, >100%) was compared using one-way ANOVA. Significance was set at alpha = 0.025. Results Mean age was 7.2 ± 4.1 years, life expectancy 59.8 ± 33%, weight 19 ± 14 kg, and DOP 3.76 ± 1.8 mg kg-1. Among age models, only life expectancy was a predictor of DOP (-0.37 mg kg-1; P = 0.013) but of minimal clinical importance. The DOP by life age expectancy quartile was 3.9 ± 2.3, 3.8 ± 1.8, 3.6 ± 1.8, 3.7 ± 1.7, and 3.4 ± 1.6 mg kg-1, respectively (P = 0.20). Yorkshire Terrier, Chihuahua, Maltese, mixed breed dogs under 10 kg, and Shih Tzu required higher DOP. Status of neutered male, ASA E, and Boxer, Labrador and Golden Retriever breeds decreased DOP, along with certain premedication drugs. Conclusions and clinical relevance In contrast to what is observed in people, an age cut-off predictive of DOP does not exist. Percentage of elapsed life expectancy along with other factors such as breed, premedication drug, emergency procedure, and reproductive status significantly alter DOP. In older dogs, the dose of propofol can be adjusted based on their elapsed life expectancy.
dc.description.confidentialfalse
dc.identifier.citationHampton CE, da Cunha A, Desselle A, Queiroz-Williams P, Hofmeister EH. (2023). The effect of age on the induction dose of propofol for general anesthesia in dogs. Plos One. 18. 7 July.
dc.identifier.doi10.1371/journal.pone.0288088
dc.identifier.eissn1932-6203
dc.identifier.elements-typejournal-article
dc.identifier.numbere0288088
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/73706
dc.languageEnglish
dc.publisherPLOS
dc.publisher.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288088
dc.relation.isPartOfPlos One
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe effect of age on the induction dose of propofol for general anesthesia in dogs
dc.typeJournal article
pubs.elements-id503608
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
503608 PDF.pdf
Size:
471.16 KB
Format:
Adobe Portable Document Format
Description:
Evidence
Download
Thumbnail Image
Name:
pone.0288088.s001.xlsx
Size:
749.11 KB
Format:
Microsoft Excel
Description:
Evidence
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles