The effects of ruminant milk treatments on hippocampal, striatal, and prefrontal cortex gene expression in pigs as a model for the human infant

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dc.citation.volume16
dc.contributor.authorJena A
dc.contributor.authorMontoya CA
dc.contributor.authorYoung W
dc.contributor.authorMullaney JA
dc.contributor.authorRoy D
dc.contributor.authorDilger RN
dc.contributor.authorGiezenaar C
dc.contributor.authorMcNabb WC
dc.contributor.authorRoy NC
dc.contributor.editorLim CK
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-10-18T02:19:28Z
dc.date.accessioned2023-10-19T20:38:35Z
dc.date.available2022-08-15
dc.date.available2023-10-18T02:19:28Z
dc.date.available2023-10-19T20:38:35Z
dc.date.issued2022-08-15
dc.date.updated2023-10-17T20:36:04Z
dc.description.abstractWhile infant formula is usually bovine milk-based, interest in other ruminant milk-based formulas is growing. However, whether different ruminant milk treatments with varying nutrient compositions influence the infant's brain development remains unknown. The aim was to determine the effects of consuming bovine, caprine, or ovine milk on brain gene expression in the early postnatal period using a pig model of the human infant. Starting at postnatal day 7 or 8, pigs were exclusively fed bovine, ovine, or caprine milk for 15 days. The mRNA abundance of 77 genes in the prefrontal cortex, hippocampus, and striatum regions was measured at postnatal day 21 or 22 using NanoString. The expression level of two hippocampal and nine striatal genes was most affected by milk treatments, particularly ovine milk. These modulatory genes are involved in glutamate, gamma-aminobutyric acid, serotonin, adrenaline and neurotrophin signaling and the synaptic vesicle cycle. The expression level of genes involved in gamma-aminobutyric acid signaling was associated with pigs' lactose intake. In contrast, milk treatments did not affect the mRNA abundance of the genes in the prefrontal cortex. This study provides the first evidence of the association of different ruminant milk treatments with brain gene expression related to cognitive function in the first 3 months of postnatal life.
dc.description.confidentialfalse
dc.format.extent937845-
dc.identifier937845
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/36046471
dc.identifier.citationJena A, Montoya CA, Young W, Mullaney JA, Roy D, Dilger RN, Giezenaar C, McNabb WC, Roy NC. (2022). The effects of ruminant milk treatments on hippocampal, striatal, and prefrontal cortex gene expression in pigs as a model for the human infant.. Front Neurosci. 16. (pp. 937845-).
dc.identifier.doi10.3389/fnins.2022.937845
dc.identifier.eissn1662-453X
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1662-4548
dc.identifier.urihttp://hdl.handle.net/10179/20334
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/articles/10.3389/fnins.2022.937845/ful
dc.relation.isPartOfFront Neurosci
dc.rights(c) 2022 The Author/sen_US
dc.rightsCC BYen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectbrain gene expression
dc.subjectcognition
dc.subjectearly life
dc.subjectgut-brain axis
dc.subjectnutrition
dc.subjectpig
dc.subjectruminant milk
dc.titleThe effects of ruminant milk treatments on hippocampal, striatal, and prefrontal cortex gene expression in pigs as a model for the human infant
dc.typeJournal article
pubs.elements-id455738
pubs.organisational-groupOther
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