Genomic Characterization of Canis Familiaris Papillomavirus Type 25, a Novel Papillomavirus Associated with a Viral Plaque from the Pinna of a Dog

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dc.citation.issue11
dc.citation.volume13
dc.contributor.authorMunday JS
dc.contributor.authorGedye K
dc.contributor.authorKnox MA
dc.contributor.authorRobinson L
dc.contributor.authorLin X
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-05-28T21:40:23Z
dc.date.available2024-05-28T21:40:23Z
dc.date.issued2023-06-02
dc.description.abstractA 14-year-old West Highland White terrier dog developed multiple raised plaques that were confined to the concave surface of the right pinna. Histology allowed a diagnosis of viral plaque, although the lesions contained some unusual microscopic features. A papillomaviral (PV) DNA sequence was amplified from the plaque using consensus PCR primers. The amplified sequence was used as a template to design 'outward facing' PCR primers, which allowed amplification of the complete PV DNA sequence. The sequence was 7778 bp and was predicted to code for five early genes and two late genes. The ORF L1 showed the highest (83.9%) similarity to CPV15, and phylogenetic analysis revealed the novel PV clustered with the species 3 ChiPVs. The novel PV was designated as canine papillomavirus (CPV) type 25. As CPV25 was not previously detected in a canine viral plaque, this PV type may be a rare cause of skin disease in dogs. However, as plaques that remain confined to the pinna were not previously reported in dogs, it is possible that CPV25 could be more common in plaques from this area of skin. The findings from this case expand the number of PV types that cause disease in dogs. Evidence from this case suggests that, compared to the other canine ChiPV types, infection by CPV25 results in viral plaques in atypical locations with unusual histological features.
dc.description.confidentialfalse
dc.edition.editionJune-1 2023
dc.format.pagination1859-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37889803
dc.identifier.citationMunday JS, Gedye K, Knox MA, Robinson L, Lin X. (2023). Genomic Characterization of Canis Familiaris Papillomavirus Type 25, a Novel Papillomavirus Associated with a Viral Plaque from the Pinna of a Dog.. Animals (Basel). 13. 11. (pp. 1859-).
dc.identifier.doi10.3390/ani13111859
dc.identifier.eissn2076-2615
dc.identifier.elements-typejournal-article
dc.identifier.issn2076-2615
dc.identifier.number1859
dc.identifier.piiani13111859
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69671
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2076-2615/13/11/1859
dc.relation.isPartOfAnimals (Basel)
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectCPV
dc.subjectCPV25
dc.subjectcanine papillomavirus
dc.subjectdog
dc.subjectneoplasia
dc.subjectpapillomavirus
dc.subjectpigmented plaque
dc.subjectskin
dc.subjectviral plaque
dc.titleGenomic Characterization of Canis Familiaris Papillomavirus Type 25, a Novel Papillomavirus Associated with a Viral Plaque from the Pinna of a Dog
dc.typeJournal article
pubs.elements-id477838
pubs.organisational-groupOther
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