Hydrogen cross-feeders of the human gastrointestinal tract.

Simple item page
dc.citation.issue3
dc.citation.volume10
dc.contributor.authorSmith NW
dc.contributor.authorShorten PR
dc.contributor.authorAltermann EH
dc.contributor.authorRoy NC
dc.contributor.authorMcNabb WC
dc.coverage.spatialUnited States
dc.date.accessioned2024-08-13T21:57:14Z
dc.date.available2024-08-13T21:57:14Z
dc.date.issued2019-01-01
dc.description.abstractHydrogen plays a key role in many microbial metabolic pathways in the human gastrointestinal tract (GIT) that have an impact on human nutrition, health and wellbeing. Hydrogen is produced by many members of the GIT microbiota, and may be subsequently utilized by cross-feeding microbes for growth and in the production of larger molecules. Hydrogenotrophic microbes fall into three functional groups: sulfate-reducing bacteria, methanogenic archaea and acetogenic bacteria, which can convert hydrogen into hydrogen sulfide, methane and acetate, respectively. Despite different energy yields per molecule of hydrogen used between the functional groups, all three can coexist in the human GIT. The factors affecting the numerical balance of hydrogenotrophs in the GIT remain unconfirmed. There is increasing evidence linking both hydrogen sulfide and methane to GIT diseases such as irritable bowel syndrome, and strategies for the mitigation of such health problems through targeting of hydrogenotrophs constitute an important field for further investigation.
dc.description.confidentialfalse
dc.edition.edition2019
dc.format.pagination270-288
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30563420
dc.identifier.citationSmith NW, Shorten PR, Altermann EH, Roy NC, McNabb WC. (2019). Hydrogen cross-feeders of the human gastrointestinal tract.. Gut Microbes. 10. 3. (pp. 270-288).
dc.identifier.doi10.1080/19490976.2018.1546522
dc.identifier.eissn1949-0984
dc.identifier.elements-typejournal-article
dc.identifier.issn1949-0976
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71275
dc.languageeng
dc.publisherTaylor & Francis Group
dc.publisher.urihttps://www.tandfonline.com/doi/full/10.1080/19490976.2018.1546522
dc.relation.isPartOfGut Microbes
dc.rights(c) 2018 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
dc.subjectbacteria
dc.subjectcolorectal cancer
dc.subjectcross-feeding
dc.subjectgastrointestinal
dc.subjectinflammatory bowel disease
dc.subjectirritable bowel syndrome
dc.subjectmethane
dc.subjectmicrobiota
dc.subjectsulfate-reducing bacteria
dc.subjectsulfide
dc.subjectAcetates
dc.subjectAnimals
dc.subjectArchaea
dc.subjectBacteria
dc.subjectGastrointestinal Diseases
dc.subjectGastrointestinal Microbiome
dc.subjectHumans
dc.subjectHydrogen
dc.subjectHydrogen Sulfide
dc.subjectMethane
dc.titleHydrogen cross-feeders of the human gastrointestinal tract.
dc.typeJournal article
pubs.elements-id419309
pubs.organisational-groupOther
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