Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk

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dc.citation.volumeOnline
dc.contributor.authorTian Y
dc.contributor.authorLin Y
dc.contributor.authorQu C
dc.contributor.authorArndt V
dc.contributor.authorBaurley JW
dc.contributor.authorBerndt SI
dc.contributor.authorBien SA
dc.contributor.authorBishop DT
dc.contributor.authorBrenner H
dc.contributor.authorBuchanan DD
dc.contributor.authorBudiarto A
dc.contributor.authorCampbell PT
dc.contributor.authorCarreras-Torres R
dc.contributor.authorCasey G
dc.contributor.authorChan AT
dc.contributor.authorChen R
dc.contributor.authorChen X
dc.contributor.authorConti DV
dc.contributor.authorDíez-Obrero V
dc.contributor.authorDimou N
dc.contributor.authorDrew DA
dc.contributor.authorFigueiredo JC
dc.contributor.authorGallinger S
dc.contributor.authorGiles GG
dc.contributor.authorGruber SB
dc.contributor.authorGunter MJ
dc.contributor.authorHarlid S
dc.contributor.authorHarrison TA
dc.contributor.authorHidaka A
dc.contributor.authorHoffmeister M
dc.contributor.authorHuyghe JR
dc.contributor.authorJenkins MA
dc.contributor.authorJordahl KM
dc.contributor.authorJoshi AD
dc.contributor.authorKeku TO
dc.contributor.authorKawaguchi E
dc.contributor.authorKim AE
dc.contributor.authorKundaje A
dc.contributor.authorLarsson SC
dc.contributor.authorMarchand LL
dc.contributor.authorLewinger JP
dc.contributor.authorLi L
dc.contributor.authorMoreno V
dc.contributor.authorMorrison J
dc.contributor.authorMurphy N
dc.contributor.authorNan H
dc.contributor.authorNassir R
dc.contributor.authorNewcomb PA
dc.contributor.authorObón-Santacana M
dc.contributor.authorOgino S
dc.contributor.authorOse J
dc.contributor.authorPardamean B
dc.contributor.authorPellatt AJ
dc.contributor.authorPeoples AR
dc.contributor.authorPlatz EA
dc.contributor.authorPotter JD
dc.contributor.authorPrentice RL
dc.contributor.authorRennert G
dc.contributor.authorRuiz-Narvaez EA
dc.contributor.authorSakoda LC
dc.contributor.authorSchoen RE
dc.contributor.authorShcherbina A
dc.contributor.authorStern MC
dc.contributor.authorSu Y-R
dc.contributor.authorThibodeau SN
dc.contributor.authorThomas DC
dc.contributor.authorTsilidis KK
dc.contributor.authorvan Duijnhoven FJB
dc.contributor.authorVan Guelpen B
dc.contributor.authorVisvanathan K
dc.contributor.authorWhite E
dc.contributor.authorWolk A
dc.contributor.authorWoods MO
dc.contributor.authorWu AH
dc.contributor.authorPeters U
dc.contributor.authorGauderman WJ
dc.contributor.authorHsu L
dc.contributor.authorChang-Claude J
dc.coverage.spatialEngland
dc.date.accessioned2024-04-08T01:46:50Z
dc.date.accessioned2024-07-25T06:49:50Z
dc.date.available2024-04
dc.date.available2024-04-08T01:46:50Z
dc.date.available2024-07-25T06:49:50Z
dc.date.issued2024-04-01
dc.description.abstractBACKGROUND: Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT risk-benefit assessment, we aimed to evaluate the joint association of a polygenic risk score (PRS) for CRC and MHT on CRC risk. METHODS: We used data from 28,486 postmenopausal women (11,519 cases and 16,967 controls) of European descent. A PRS based on 141 CRC-associated genetic variants was modeled as a categorical variable in quartiles. Multiplicative interaction between PRS and MHT use was evaluated using logistic regression. Additive interaction was measured using the relative excess risk due to interaction (RERI). 30-year cumulative risks of CRC for 50-year-old women according to MHT use and PRS were calculated. RESULTS: The reduction in odds ratios by MHT use was larger in women within the highest quartile of PRS compared to that in women within the lowest quartile of PRS (p-value = 2.7 × 10-8). At the highest quartile of PRS, the 30-year CRC risk was statistically significantly lower for women taking any MHT than for women not taking any MHT, 3.7% (3.3%-4.0%) vs 6.1% (5.7%-6.5%) (difference 2.4%, P-value = 1.83 × 10-14); these differences were also statistically significant but smaller in magnitude in the lowest PRS quartile, 1.6% (1.4%-1.8%) vs 2.2% (1.9%-2.4%) (difference 0.6%, P-value = 1.01 × 10-3), indicating 4 times greater reduction in absolute risk associated with any MHT use in the highest compared to the lowest quartile of genetic CRC risk. CONCLUSIONS: MHT use has a greater impact on the reduction of CRC risk for women at higher genetic risk. These findings have implications for the development of risk prediction models for CRC and potentially for the consideration of genetic information in the risk-benefit assessment of MHT use.
dc.description.confidentialfalse
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38561434
dc.identifier.citationTian Y, Lin Y, Qu C, Arndt V, Baurley JW, Berndt SI, Bien SA, Bishop DT, Brenner H, Buchanan DD, Budiarto A, Campbell PT, Carreras-Torres R, Casey G, Chan AT, Chen R, Chen X, Conti DV, Díez-Obrero V, Dimou N, Drew DA, Figueiredo JC, Gallinger S, Giles GG, Gruber SB, Gunter MJ, Harlid S, Harrison TA, Hidaka A, Hoffmeister M, Huyghe JR, Jenkins MA, Jordahl KM, Joshi AD, Keku TO, Kawaguchi E, Kim AE, Kundaje A, Larsson SC, Marchand LL, Lewinger JP, Li L, Moreno V, Morrison J, Murphy N, Nan H, Nassir R, Newcomb PA, Obón-Santacana M, Ogino S, Ose J, Pardamean B, Pellatt AJ, Peoples AR, Platz EA, Potter JD, Prentice RL, Rennert G, Ruiz-Narvaez EA, Sakoda LC, Schoen RE, Shcherbina A, Stern MC, Su Y-R, Thibodeau SN, Thomas DC, Tsilidis KK, van Duijnhoven FJB, Van Guelpen B, Visvanathan K, White E, Wolk A, Woods MO, Wu AH, Peters U, Gauderman WJ, Hsu L, Chang-Claude J. (2024). Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk.. Br J Cancer. Online.
dc.identifier.doi10.1038/s41416-024-02638-2
dc.identifier.eissn1532-1827
dc.identifier.elements-typejournal-article
dc.identifier.issn0007-0920
dc.identifier.pii10.1038/s41416-024-02638-2
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70968
dc.languageeng
dc.publisherSpringer Nature Limited
dc.publisher.urihttps://www.nature.com/articles/s41416-024-02638-2
dc.relation.isPartOfBr J Cancer
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleGenetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
dc.typeJournal article
pubs.elements-id488067
pubs.organisational-groupOther
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