Marine Fish-Derived Lysophosphatidylcholine: Properties, Extraction, Quantification, and Brain Health Application

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dc.citation.issue7
dc.citation.volume28
dc.contributor.authorAhmmed MK
dc.contributor.authorHachem M
dc.contributor.authorAhmmed F
dc.contributor.authorRashidinejad A
dc.contributor.authorOz F
dc.contributor.authorBekhit AA
dc.contributor.authorCarne A
dc.contributor.authorBekhit AE-DA
dc.contributor.editorJembrek MJ
dc.contributor.editorŠegota S
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-05-17T02:58:44Z
dc.date.available2024-05-17T02:58:44Z
dc.date.issued2023-03-30
dc.description.abstractLong-chain omega-3 fatty acids esterified in lysophosphatidylcholine (LPC-omega-3) are the most bioavailable omega-3 fatty acid form and are considered important for brain health. Lysophosphatidylcholine is a hydrolyzed phospholipid that is generated from the action of either phospholipase PLA1 or PLA2. There are two types of LPC; 1-LPC (where the omega-3 fatty acid at the sn-2 position is acylated) and 2-LPC (where the omega-3 fatty acid at the sn-1 position is acylated). The 2-LPC type is more highly bioavailable to the brain than the 1-LPC type. Given the biological and health aspects of LPC types, it is important to understand the structure, properties, extraction, quantification, functional role, and effect of the processing of LPC. This review examines various aspects involved in the extraction, characterization, and quantification of LPC. Further, the effects of processing methods on LPC and the potential biological roles of LPC in health and wellbeing are discussed. DHA-rich-LysoPLs, including LPC, can be enzymatically produced using lipases and phospholipases from wide microbial strains, and the highest yields were obtained by Lipozyme RM-IM®, Lipozyme TL-IM®, and Novozym 435®. Terrestrial-based phospholipids generally contain lower levels of long-chain omega-3 PUFAs, and therefore, they are considered less effective in providing the same health benefits as marine-based LPC. Processing (e.g., thermal, fermentation, and freezing) reduces the PL in fish. LPC containing omega-3 PUFA, mainly DHA (C22:6 omega-3) and eicosapentaenoic acid EPA (C20:5 omega-3) play important role in brain development and neuronal cell growth. Additionally, they have been implicated in supporting treatment programs for depression and Alzheimer's. These activities appear to be facilitated by the acute function of a major facilitator superfamily domain-containing protein 2 (Mfsd2a), expressed in BBB endothelium, as a chief transporter for LPC-DHA uptake to the brain. LPC-based delivery systems also provide the opportunity to improve the properties of some bioactive compounds during storage and absorption. Overall, LPCs have great potential for improving brain health, but their safety and potentially negative effects should also be taken into consideration.
dc.description.confidentialfalse
dc.edition.editionApril 2023
dc.format.pagination3088-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37049852
dc.identifier.citationAhmmed MK, Hachem M, Ahmmed F, Rashidinejad A, Oz F, Bekhit AA, Carne A, Bekhit AE-DA. (2023). Marine Fish-Derived Lysophosphatidylcholine: Properties, Extraction, Quantification, and Brain Health Application.. Molecules. 28. 7. (pp. 3088-).
dc.identifier.doi10.3390/molecules28073088
dc.identifier.eissn1420-3049
dc.identifier.elements-typejournal-article
dc.identifier.issn1420-3049
dc.identifier.number3088
dc.identifier.piimolecules28073088
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69589
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/1420-3049/28/7/3088
dc.relation.isPartOfMolecules
dc.rightsCC BY 4.0
dc.rights(c) 2023 The Author/s
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMfsd2a transporter
dc.subjectbioactive compounds
dc.subjectcognitive function
dc.subjectdisease management
dc.subjectdrug delivery
dc.subjectmarine lysophosphatidylcholine (LPC)
dc.subjectmental wellness
dc.subjectneural health
dc.subjectomega-3 supplementation
dc.subjectprocessing impact
dc.subjectstructural properties
dc.subjectAnimals
dc.subjectLysophosphatidylcholines
dc.subjectBrain
dc.subjectFatty Acids, Omega-3
dc.subjectMembrane Transport Proteins
dc.subjectBiological Transport
dc.subjectEicosapentaenoic Acid
dc.subjectPhospholipids
dc.subjectFatty Acids
dc.subjectDocosahexaenoic Acids
dc.titleMarine Fish-Derived Lysophosphatidylcholine: Properties, Extraction, Quantification, and Brain Health Application
dc.typeJournal article
pubs.elements-id461030
pubs.organisational-groupOther
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