Population Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa.

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dc.citation.issue10
dc.citation.volume30
dc.contributor.authorFrench NP
dc.contributor.authorThomas KM
dc.contributor.authorAmani NB
dc.contributor.authorBenschop J
dc.contributor.authorBigogo GM
dc.contributor.authorCleaveland S
dc.contributor.authorFayaz A
dc.contributor.authorHugho EA
dc.contributor.authorKarimuribo ED
dc.contributor.authorKasagama E
dc.contributor.authorMaganga R
dc.contributor.authorMelubo ML
dc.contributor.authorMidwinter AC
dc.contributor.authorMmbaga BT
dc.contributor.authorMosha VV
dc.contributor.authorMshana FI
dc.contributor.authorMunyua P
dc.contributor.authorOchieng JB
dc.contributor.authorRogers L
dc.contributor.authorSindiyo E
dc.contributor.authorSwai ES
dc.contributor.authorVerani JR
dc.contributor.authorWiddowson M-A
dc.contributor.authorWilkinson DA
dc.contributor.authorKazwala RR
dc.contributor.authorCrump JA
dc.contributor.authorZadoks RN
dc.coverage.spatialUnited States
dc.date.accessioned2024-10-08T19:48:23Z
dc.date.available2024-10-08T19:48:23Z
dc.date.issued2024-10
dc.description.abstractCampylobacteriosis and antimicrobial resistance (AMR) are global public health concerns. Africa is estimated to have the world's highest incidence of campylobacteriosis and a relatively high prevalence of AMR in Campylobacter spp. from humans and animals. Few studies have compared Campylobacter spp. isolated from humans and poultry in Africa using whole-genome sequencing and antimicrobial susceptibility testing. We explored the population structure and AMR of 178 Campylobacter isolates from East Africa, 81 from patients with diarrhea in Kenya and 97 from 56 poultry samples in Tanzania, collected during 2006-2017. Sequence type diversity was high in both poultry and human isolates, with some sequence types in common. The estimated prevalence of multidrug resistance, defined as resistance to >3 antimicrobial classes, was higher in poultry isolates (40.9%, 95% credible interval 23.6%-59.4%) than in human isolates (2.5%, 95% credible interval 0.3%-6.8%), underlining the importance of antimicrobial stewardship in livestock systems.
dc.description.confidentialfalse
dc.edition.editionOctober 2024
dc.format.pagination2079-2089
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/39320160
dc.identifier.citationFrench NP, Thomas KM, Amani NB, Benschop J, Bigogo GM, Cleaveland S, Fayaz A, Hugho EA, Karimuribo ED, Kasagama E, Maganga R, Melubo ML, Midwinter AC, Mmbaga BT, Mosha VV, Mshana FI, Munyua P, Ochieng JB, Rogers L, Sindiyo E, Swai ES, Verani JR, Widdowson M-A, Wilkinson DA, Kazwala RR, Crump JA, Zadoks RN. (2024). Population Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa.. Emerg Infect Dis. 30. 10. (pp. 2079-2089).
dc.identifier.doi10.3201/eid3010.231399
dc.identifier.eissn1080-6059
dc.identifier.elements-typejournal-article
dc.identifier.issn1080-6040
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71625
dc.languageeng
dc.publisherCenters for Disease Control and Prevention
dc.publisher.urihttps://wwwnc.cdc.gov/eid/article/30/10/23-1399_article
dc.relation.isPartOfEmerg Infect Dis
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectCampylobacter coli
dc.subjectCampylobacter jejuni
dc.subjectKenya
dc.subjectTanzania
dc.subjectantimicrobial resistance
dc.subjectbacteria
dc.subjectcampylobacteriosis
dc.subjecteast Africa
dc.subjectenteric infections
dc.subjecthumans
dc.subjectpoultry
dc.subjectzoonoses
dc.subjectHumans
dc.subjectCampylobacter jejuni
dc.subjectAnimals
dc.subjectDiarrhea
dc.subjectCampylobacter Infections
dc.subjectPoultry
dc.subjectAnti-Bacterial Agents
dc.subjectCampylobacter coli
dc.subjectMicrobial Sensitivity Tests
dc.subjectDrug Resistance, Bacterial
dc.subjectPoultry Diseases
dc.subjectWhole Genome Sequencing
dc.subjectAfrica, Eastern
dc.subjectDrug Resistance, Multiple, Bacterial
dc.subjectPhylogeny
dc.titlePopulation Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa.
dc.typeJournal article
pubs.elements-id491773
pubs.organisational-groupOther
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