Hedgehogs as Amplifying Hosts of Severe Fever with Thrombocytopenia Syndrome Virus, China.

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dc.citation.issue12
dc.citation.volume28
dc.contributor.authorZhao C
dc.contributor.authorZhang X
dc.contributor.authorSi X
dc.contributor.authorYe L
dc.contributor.authorLawrence K
dc.contributor.authorLu Y
dc.contributor.authorDu C
dc.contributor.authorXu H
dc.contributor.authorYang Q
dc.contributor.authorXia Q
dc.contributor.authorYu G
dc.contributor.authorXu W
dc.contributor.authorYuan F
dc.contributor.authorHao J
dc.contributor.authorJiang J-F
dc.contributor.authorZheng A
dc.coverage.spatialUnited States
dc.date.available2022-12
dc.date.issued2022-12
dc.description.abstractSevere fever with thrombocytopenia syndrome virus (SFTSV) is a tickborne bandavirus mainly transmitted by Haemaphysalis longicornis ticks in East Asia, mostly in rural areas. As of April 2022, the amplifying host involved in the natural transmission of SFTSV remained unidentified. Our epidemiologic field survey conducted in endemic areas in China showed that hedgehogs were widely distributed, had heavy tick infestations, and had high SFTSV seroprevalence and RNA prevalence. After experimental infection of Erinaceus amurensis and Atelerix albiventris hedgehogs with SFTSV, we detected robust but transitory viremias that lasted for 9-11 days. We completed the SFTSV transmission cycle between hedgehogs and nymph and adult H. longicornis ticks under laboratory conditions with 100% efficiency. Furthermore, naive H. longicornis ticks could be infected by SFTSV-positive ticks co-feeding on naive hedgehogs; we confirmed transstadial transmission of SFTSV. Our study suggests that the hedgehogs are a notable wildlife amplifying host of SFTSV in China.
dc.description.publication-statusPublished
dc.format.extent2491 - 2499
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/36417938
dc.identifier.citationEmerg Infect Dis, 2022, 28 (12), pp. 2491 - 2499
dc.identifier.doi10.3201/eid2812.220668
dc.identifier.eissn1080-6059
dc.identifier.elements-id458520
dc.identifier.harvestedMassey_Dark
dc.languageeng
dc.relation.isPartOfEmerg Infect Dis
dc.rights(c) The author/s CC BY 4.0
dc.subjectChina
dc.subjectHaemaphysalis longicornis
dc.subjectSFTSV
dc.subjectamplifying host
dc.subjectbandavirus
dc.subjecthedgehog
dc.subjectsevere fever with thrombocytopenia syndrome
dc.subjectsevere fever with thrombocytopenia syndrome virus
dc.subjecttick
dc.subjecttransmission
dc.subjectvector-borne infections
dc.subjectviruses
dc.subjectzoonoses
dc.subjectAnimals
dc.subjectSevere Fever with Thrombocytopenia Syndrome
dc.subjectHedgehogs
dc.subjectSeroepidemiologic Studies
dc.subjectPhylogeny
dc.subjectPhlebovirus
dc.subjectTicks
dc.subjectChina
dc.subject.anzsrc1103 Clinical Sciences
dc.subject.anzsrc1108 Medical Microbiology
dc.subject.anzsrc1117 Public Health and Health Services
dc.titleHedgehogs as Amplifying Hosts of Severe Fever with Thrombocytopenia Syndrome Virus, China.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
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