Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up

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dc.citation.issue1
dc.citation.volume16
dc.contributor.authorWilson BC
dc.contributor.authorZuppi M
dc.contributor.authorDerraik JGB
dc.contributor.authorAlbert BB
dc.contributor.authorTweedie-Cullen RY
dc.contributor.authorLeong KSW
dc.contributor.authorBeck KL
dc.contributor.authorVatanen T
dc.contributor.authorO'Sullivan JM
dc.contributor.authorCutfield WS
dc.contributor.authorStudy Group GB
dc.date.accessioned2025-09-24T20:54:57Z
dc.date.available2025-09-24T20:54:57Z
dc.date.issued2025-08-28
dc.description.abstractFaecal microbiota transplantation (FMT) has been explored as a potential treatment for obesity, but its long-term effects on metabolic health remain unclear. Here, we report 4-year follow-up findings from a double-blind, randomised, placebo-controlled trial assessing FMT in adolescents with obesity (ACTRN12615001351505, Australian New Zealand Clinical Trials Registry). This unblinded follow-up study evaluated 63% (55/87) of the original participants (27 FMT, 28 placebo). There was no difference in BMI between the two groups, after adjusting for sex, age, diet, and physical activity (-3.6 kg/m2, p = 0.095). However, FMT recipients showed clinical improvements in body composition and metabolic health compared to the placebo group. Specifically, FMT recipients had smaller waist circumference (-10.0 cm, p = 0.026), total body fat (-4.8%, p = 0.024), metabolic syndrome severity score (-0.58, p = 0.003), and systemic inflammation (-68% hs-CRP, p = 0.002) and higher levels of HDL cholesterol (0.16 mmol/L, p = 0.037). No group differences were observed in glucose markers, or other lipid parameters. Shotgun metagenomic sequencing revealed sustained long-term alterations in gut microbiome richness, composition and functional capacity, with persistence of donor-derived bacterial and bacteriophage strains. These findings highlight the potential relevance of FMT as a microbiome-augmenting intervention for obesity management and metabolic health, warranting further investigation.
dc.description.confidentialfalse
dc.format.pagination7786-
dc.identifier.citationWilson BC, Zuppi M, Derraik JGB, Albert BB, Tweedie-Cullen RY, Leong KSW, Beck KL, Vatanen T, O'Sullivan JM, Cutfield WS. (2025). Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up. Nature Communications. 16. 1. (pp. 7786-).
dc.identifier.doi10.1038/s41467-025-62752-4
dc.identifier.eissn2041-1723
dc.identifier.elements-typejournal-article
dc.identifier.number7786
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/73603
dc.languageEnglish
dc.publisherSpringer Nature Limited
dc.publisher.urihttp://nature.com/articles/s41467-025-62752-4
dc.relation.isPartOfNature Communications
dc.rights(c) 2025 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleLong-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up
dc.typeJournal article
pubs.elements-id503258
pubs.organisational-groupOther
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