Small daily doses of orange heirloom (“Moonglow”) tomatoes dose-dependently increase plasma and liver lycopene concentrations in rats

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dc.citation.issue6
dc.citation.volume89
dc.contributor.authorWalallawita US
dc.contributor.authorWolber FM
dc.contributor.authorZiv-Gal A
dc.contributor.authorKruger MC
dc.contributor.authorHeyes JA
dc.contributor.authorWalallawita Kankanamge U
dc.date.accessioned2025-05-27T01:49:57Z
dc.date.available2025-05-27T01:49:57Z
dc.date.issued2025-03-08
dc.description.abstractLycopene in red tomatoes is mainly in the poorly bioavailable all-trans- isomeric form, while “Moonglow,” an orange heirloom tomato, contains more bioavailable cis-lycopene isomers. Consuming around 1.5 kg of red tomatoes daily is needed to achieve effective plasma lycopene levels (>0.45 µmol/L). This study hypothesized that small daily doses of “Moonglow” tomatoes could achieve beneficial lycopene levels in rats. Female Sprague-Dawley rats were supplemented with “Moonglow” tomato powder. In Study 1, rats received lycopene at 0, 0.05, 0.35, or 2.6 mg/kg body weight daily for five days. Plasma and liver lycopene concentrations increased dose-dependently. In Study 2, rats given 0.35 mg/kg daily showed dose- and time-dependent increases in lycopene. Plasma lycopene reached 0.42 µmol/L after 4 days, similar to beneficial human levels. These findings suggest that a reasonable daily intake of “Moonglow” tomatoes can achieve effective plasma lycopene concentrations.
dc.description.confidentialfalse
dc.edition.editionJune 2025
dc.format.pagination876-883
dc.identifier.citationWalallawita US, Wolber FM, Ziv-Gal A, Kruger MC, Heyes JA, Walallawita Kankanamge U. (2025). Small daily doses of orange heirloom (“Moonglow”) tomatoes dose-dependently increase plasma and liver lycopene concentrations in rats. Bioscience, Biotechnology, and Biochemistry. 89. 6. (pp. 876-883).
dc.identifier.doi10.1093/bbb/zbaf027
dc.identifier.eissn1347-6947
dc.identifier.elements-typejournal-article
dc.identifier.issn0916-8451
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72948
dc.languageEnglish
dc.publisherOxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry
dc.publisher.urihttp://academic.oup.com/bbb/article/89/6/876/8064773
dc.relation.isPartOfBioscience, Biotechnology, and Biochemistry
dc.rights(c) 2025 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleSmall daily doses of orange heirloom (“Moonglow”) tomatoes dose-dependently increase plasma and liver lycopene concentrations in rats
dc.typeJournal article
pubs.elements-id500831
pubs.organisational-groupOther
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