Relationship between vitamin D, iron, and hepcidin in premenopausal females, potentially confounded by ethnicity.

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dc.citation.issue8
dc.citation.volume62
dc.contributor.authorGreenwood A
dc.contributor.authorVon Hurst PR
dc.contributor.authorBeck KL
dc.contributor.authorMazahery H
dc.contributor.authorLim K
dc.contributor.authorBadenhorst CE
dc.coverage.spatialGermany
dc.date.accessioned2024-06-19T02:00:32Z
dc.date.available2024-06-19T02:00:32Z
dc.date.issued2023-08-29
dc.description.abstractPURPOSE: To investigate the associations between vitamin D, hepcidin, and iron status in premenopausal females of different ethnic cohorts residing in Auckland, New Zealand (NZ). METHODS: A total of 160 females aged 18-45 years participated in a cross-sectional study. Demographics, body composition, serum 25(OH)D, inflammatory markers (C-reactive protein and interleukin-6, IL-6), and iron biomarkers (serum ferritin, haemoglobin, soluble transferrin receptor, and hepcidin) were measured. Comparisons between parametric, non-parametric, and categorical variables were completed by using one-way ANOVA, Kruskal-Wallis, and Chi-squared tests, respectively. ANCOVA was used to compare serum 25(OH)D across iron parameter categories. RESULTS: Of the 160 participants, 60 were NZ European, 67 were South Asian, and 33 were from the 'other' ethnic groups. South Asians had significantly higher body fat percentage (BF%) and IL-6 concentration (38.34% and 1.66 pg·mL-1, respectively), compared to NZ Europeans (27.49% and 0.63 pg·mL-1, respectively, p < 0.001). South Asians had significantly lower 25(OH)D concentrations compared to NZ Europeans (33.59 nmol·L-1 vs 74.84 nmol·L-1, p < 0.001). In NZ Europeans, higher 25(OH)D concentration was seen in those with lower (≤ 3.5 nM) hepcidin concentration, p = 0.0046. In South Asians, higher 25(OH)D concentration was seen in those with higher (> 3.5 nM) hepcidin concentrations, p = 0.038. There were no associations between serum 25(OH)D and serum ferritin. CONCLUSION: Within South Asian women, an unexpected positive relationship between 25(OH)D and hepcidin concentration was observed which may be due to significantly higher IL-6 concentrations, BF%, and lower 25(OH)D concentrations. Future research is required to confirm these observations in this ethnic cohort.
dc.description.confidentialfalse
dc.format.pagination3361-3368
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37642748
dc.identifier.citationGreenwood A, von Hurst PR, Beck KL, Mazahery H, Lim K, Badenhorst CE. (2023). Relationship between vitamin D, iron, and hepcidin in premenopausal females, potentially confounded by ethnicity.. Eur J Nutr. 62. 8. (pp. 3361-3368).
dc.identifier.doi10.1007/s00394-023-03240-7
dc.identifier.eissn1436-6215
dc.identifier.elements-typejournal-article
dc.identifier.issn1436-6207
dc.identifier.pii10.1007/s00394-023-03240-7
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69909
dc.languageeng
dc.publisherSpringer Nature
dc.publisher.urihttps://link.springer.com/article/10.1007/s00394-023-03240-7
dc.relation.isPartOfEur J Nutr
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectIron regulation
dc.subjectSerum 25(OH)D
dc.subjectSerum ferritin
dc.subjectSouth Asian
dc.subjectVitamin D status
dc.subjectFemale
dc.subjectHumans
dc.subjectCross-Sectional Studies
dc.subjectEthnicity
dc.subjectFerritins
dc.subjectHepcidins
dc.subjectInterleukin-6
dc.subjectIron
dc.subjectVitamin D
dc.subjectVitamins
dc.subjectAdolescent
dc.subjectYoung Adult
dc.subjectAdult
dc.subjectMiddle Aged
dc.titleRelationship between vitamin D, iron, and hepcidin in premenopausal females, potentially confounded by ethnicity.
dc.typeJournal article
pubs.elements-id480004
pubs.organisational-groupCollege of Health
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