Siblings, asthma, rhinoconjunctivitis and eczema: a worldwide perspective from the International Study of Asthma and Allergies in Childhood.

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dc.citation.issue1
dc.citation.volume45
dc.contributor.authorStrachan DP
dc.contributor.authorAït-Khaled N
dc.contributor.authorFoliaki S
dc.contributor.authorMallol J
dc.contributor.authorOdhiambo J
dc.contributor.authorPearce N
dc.contributor.authorWilliams HC
dc.contributor.authorISAAC Phase Three Study Group
dc.date.available2015-01-01
dc.date.available2014-05-13
dc.date.issued2015-01
dc.description.abstractBACKGROUND: Associations of larger families with lower prevalences of hay fever, eczema and objective markers of allergic sensitization have been found fairly consistently in affluent countries, but little is known about these relationships in less affluent countries. METHODS: Questionnaire data for 210,200 children aged 6-7 years from 31 countries, and 337,226 children aged 13-14 years from 52 countries, were collected by Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC). Associations of disease symptoms and labels of asthma, rhinoconjunctivitis and eczema were analysed by numbers of total, older and younger siblings, using mixed (multi-level) logistic regression models to adjust for individual covariates and at the centre level for region, language and national affluence. RESULTS: In both age groups, inverse trends (P < 0.0001) were observed for reported 'hay fever ever' and 'eczema ever' with increasing numbers of total siblings, and more specifically older siblings. These inverse associations were significantly (P < 0.005) stronger in more affluent countries. In contrast, symptoms of severe asthma and severe eczema were positively associated (P < 0.0001) with total sibship size in both age groups. These associations with disease severity were largely independent of position within the sibship and national GNI per capita. CONCLUSIONS: These global findings on sibship size and childhood asthma, rhinoconjunctivitis and eczema suggest at least two distinct trends. Inverse associations with older siblings (observations which prompted the 'hygiene hypothesis' for allergic disease) are mainly a phenomenon of more affluent countries, whereas greater severity of symptoms in larger families is globally more widespread.
dc.description.publication-statusPublished
dc.format.extent126 - 136 (11)
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346910800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationCLINICAL AND EXPERIMENTAL ALLERGY, 2015, 45 (1), pp. 126 - 136 (11)
dc.identifier.doi10.1111/cea.12349
dc.identifier.elements-id220302
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0954-7894
dc.identifier.urihttps://hdl.handle.net/10179/12474
dc.languageEnglish
dc.publisherWILEY-BLACKWELL
dc.relation.isPartOfCLINICAL AND EXPERIMENTAL ALLERGY
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectAllergy
dc.subjectImmunology
dc.subjectallergic rhinitis
dc.subjectasthma
dc.subjectatopic dermatitis
dc.subjectbirth order
dc.subjecteczema
dc.subjecthay fever
dc.subjectinternational
dc.subjectsiblings
dc.subjectDAY-CARE ATTENDANCE
dc.subjectFAMILY-SIZE
dc.subjectHAY-FEVER
dc.subjectBIRTH-ORDER
dc.subjectHYGIENE HYPOTHESIS
dc.subjectEARLY-LIFE
dc.subjectATOPIC SENSITIZATION
dc.subjectNEW-ZEALAND
dc.subjectPREVALENCE
dc.subjectCHILDREN
dc.subject.anzsrc1107 Immunology
dc.subject.anzsrc1111 Nutrition and Dietetics
dc.subject.anzsrc1117 Public Health and Health Services
dc.titleSiblings, asthma, rhinoconjunctivitis and eczema: a worldwide perspective from the International Study of Asthma and Allergies in Childhood.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/Research Centre for Hauora and Health
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