Plasma metabolomic response to high-carbohydrate meals of differing glycaemic load in overweight women.

Simple item page
dc.citation.issue5
dc.citation.volume62
dc.contributor.authorDurainayagam B
dc.contributor.authorMitchell CJ
dc.contributor.authorMilan AM
dc.contributor.authorKruger MC
dc.contributor.authorRoy NC
dc.contributor.authorFraser K
dc.contributor.authorCameron-Smith D
dc.coverage.spatialGermany
dc.date.accessioned2024-07-10T02:34:39Z
dc.date.available2024-07-10T02:34:39Z
dc.date.issued2023-04-21
dc.description.abstractBACKGROUND: Metabolomic dysregulation following a meal in overweight individuals with the Metabolic Syndrome (MetS) involves multiple pathways of nutrient storage and oxidation. OBJECTIVE: The aim of the current study was to perform an acute cross-over intervention to examine the interactive actions of meal glycaemic load (GL) on the dynamic responses of the plasma metabolome in overweight females. METHODS: Postmenopausal women [63 ± 1.23y; Healthy (n = 20) and MetS (n = 20)] ingested two differing high-carbohydrate test meals (73 g carbohydrate; 51% energy) composed of either low glycemic index (LGI) or high (HGI) foods in a randomised sequence. Plasma metabolome was analysed using liquid chromatography-mass spectrometry (LC-MS). RESULTS: In the overweight women with MetS, there were suppressed postprandial responses for several amino acids (AAs), including phenylalanine, leucine, valine, and tryptophan, p < 0.05), irrespective of the meal type. Meal GL exerted a limited impact on the overall metabolomic response, although the postprandial levels of alanine were higher with the low GL meal and uric acid was greater following the high GL meal (p < 0.05). CONCLUSIONS: MetS participants exhibited reduced differences in the concentrations of a small set of AAs and a limited group of metabolites implicated in energy metabolism following the meals. However, the manipulation of meal GL had minimal impact on the postprandial metabolome. This study suggests that the GL of a meal is not a major determinant of postprandial response, with a greater impact exerted by the metabolic health of the individual. Trial registration Australia New Zealand Clinical Trials Registry: ACTRN12615001108505 (21/10/2015).
dc.description.confidentialfalse
dc.edition.editionAugust 2023
dc.format.pagination2257-2267
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37085625
dc.identifier.citationDurainayagam B, Mitchell CJ, Milan AM, Kruger MC, Roy NC, Fraser K, Cameron-Smith D. (2023). Plasma metabolomic response to high-carbohydrate meals of differing glycaemic load in overweight women.. Eur J Nutr. 62. 5. (pp. 2257-2267).
dc.identifier.doi10.1007/s00394-023-03151-7
dc.identifier.eissn1436-6215
dc.identifier.elements-typejournal-article
dc.identifier.issn1436-6207
dc.identifier.pii10.1007/s00394-023-03151-7
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70138
dc.languageeng
dc.publisherSpringer Nature
dc.publisher.urihttps://link.springer.com/article/10.1007/s00394-023-03151-7
dc.relation.isPartOfEur J Nutr
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMetabolic syndrome
dc.subjectMetabolomics
dc.subjectPostprandial
dc.subjectProtein
dc.subjectFemale
dc.subjectHumans
dc.subjectAmino Acids
dc.subjectBlood Glucose
dc.subjectCross-Over Studies
dc.subjectDietary Carbohydrates
dc.subjectGlycemic Index
dc.subjectGlycemic Load
dc.subjectInsulin
dc.subjectMeals
dc.subjectOverweight
dc.subjectPostprandial Period
dc.titlePlasma metabolomic response to high-carbohydrate meals of differing glycaemic load in overweight women.
dc.typeJournal article
pubs.elements-id461103
pubs.organisational-groupCollege of Health
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Published version.pdf
Size:
1.91 MB
Format:
Adobe Portable Document Format
Description:
461103 PDF.pdf
Download
Thumbnail Image
Name:
Evidence.docx
Size:
889.82 KB
Format:
Microsoft Word XML
Description:
394_2023_3151_MOESM1_ESM.docx
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles