Thromboelastography in obese horses with insulin dysregulation compared to healthy controls.

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dc.citation.issue3
dc.citation.volume36
dc.contributor.authorLovett AL
dc.contributor.authorGilliam LL
dc.contributor.authorSykes BW
dc.contributor.authorMcFarlane D
dc.coverage.spatialUnited States
dc.date.accessioned2024-08-14T20:12:55Z
dc.date.available2024-08-14T20:12:55Z
dc.date.issued2022-05-01
dc.description.abstractBACKGROUND: Both obesity and metabolic syndrome are associated with hypercoagulability in people, increasing the risk of cardiovascular disease and thromboembolic events. Whether hypercoagulability exists in obese, insulin-dysregulated horses is unknown. HYPOTHESIS/OBJECTIVES: To determine if coagulation profiles differ between healthy horses and those with obesity and insulin dysregulation. ANIMALS: Fifteen healthy horses (CON) and 15 obese, insulin-dysregulated horses (OBID). Individuals were university or client owned. METHODS: Case-control study. Obesity was defined as a body condition score (BCS) ≥7.5/9 (modified Henneke scale). Insulin dysregulation status was assessed by an oral sugar test (OST). Kaolin-thromboelastography and traditional coagulation variables were compared between groups. The direction and strength of the association between coagulation variables and BCS and OST results were determined using Spearman's correlation. RESULTS: Thromboelastography variables MA (OBID: 69.5 ± 4.5 mm; CON: 64.8 ± 4.3 mm; P = .007) and G-value (OBID: 11749 ± 2536 dyn/m2 ; CON: 9319 ± 1650 dyn/m2 ; P = .004) were higher in OBID compared to CON. Positive correlations between MA and BCS (R = 0.45, P = .01) and serum insulin (T0 : R = 0.45, P = .01; T60 : R = 0.39, P = .03), and G-value and BCS (R = 0.46, P = .01), and serum insulin (T0 : R = 0.48, P = .007; T60 : R = 0.43, P = .02; T90 : R = 0.38, P = .04) were present. CONCLUSIONS AND CLINICAL IMPORTANCE: Obese, insulin-dysregulated horses are hypercoagulable compared to healthy controls.
dc.description.confidentialfalse
dc.edition.editionMay 2022
dc.format.pagination1131-1138
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35429197
dc.identifier.citationLovett AL, Gilliam LL, Sykes BW, McFarlane D. (2022). Thromboelastography in obese horses with insulin dysregulation compared to healthy controls.. J Vet Intern Med. 36. 3. (pp. 1131-1138).
dc.identifier.doi10.1111/jvim.16421
dc.identifier.eissn1939-1676
dc.identifier.elements-typejournal-article
dc.identifier.issn0891-6640
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71293
dc.languageeng
dc.publisherJohn Wiley and Sons, Inc.
dc.publisher.urihttps://onlinelibrary.wiley.com/doi/10.1111/jvim.16421
dc.relation.isPartOfJ Vet Intern Med
dc.rights(c) 2022 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectequine metabolic syndrome
dc.subjecthemostasis
dc.subjecthypercoagulability
dc.subjectobesity
dc.subjectoral sugar test
dc.subjectviscoelastic testing
dc.subjectAnimals
dc.subjectCase-Control Studies
dc.subjectHorse Diseases
dc.subjectHorses
dc.subjectHumans
dc.subjectInsulin
dc.subjectObesity
dc.subjectThrombelastography
dc.subjectThrombophilia
dc.titleThromboelastography in obese horses with insulin dysregulation compared to healthy controls.
dc.typeJournal article
pubs.elements-id452938
pubs.organisational-groupOther
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