Hair and cord blood element levels and their relationship with air pollution, dietary intake, gestational diabetes mellitus, and infant neurodevelopment.

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dc.citation.issue10
dc.citation.volume42
dc.contributor.authorXia Y-Y
dc.contributor.authorde Seymour JV
dc.contributor.authorYang X-J
dc.contributor.authorZhou L-W
dc.contributor.authorLiu Y
dc.contributor.authorYang Y
dc.contributor.authorBeck KL
dc.contributor.authorConlon CA
dc.contributor.authorMansell T
dc.contributor.authorNovakovic B
dc.contributor.authorSaffery R
dc.contributor.authorHan T-L
dc.contributor.authorZhang H
dc.contributor.authorBaker PN
dc.coverage.spatialEngland
dc.date.accessioned2024-06-19T01:38:39Z
dc.date.available2024-06-19T01:38:39Z
dc.date.issued2023-08-23
dc.description.abstractBACKGROUND & AIMS: Exposure to a range of elements, air pollution, and specific dietary components in pregnancy has variously been associated with gestational diabetes mellitus (GDM) risk or infant neurodevelopmental problems. We measured a range of pregnancy exposures in maternal hair and/or infant cord serum and tested their relationship to GDM and infant neurodevelopment. METHODS: A total of 843 pregnant women (GDM = 224, Non-GDM = 619) were selected from the Complex Lipids in Mothers and Babies cohort study. Forty-eight elements in hair and cord serum were quantified using inductively coupled plasma-mass spectrometry analysis. Binary logistic regression was used to estimate the associations between hair element concentrations and GDM risk, while multiple linear regression was performed to analyze the relationship between hair/cord serum elements and air pollutants, diet exposures, and Bayley Scales of infant neurodevelopment at 12 months of age. RESULTS: After adjusting for maternal age, BMI, and primiparity, we observed that fourteen elements in maternal hair were associated with a significantly increased risk of GDM, particularly Ta (OR = 9.49, 95% CI: 6.71, 13.42), Re (OR = 5.21, 95% CI: 3.84, 7.07), and Se (OR = 5.37, 95% CI: 3.48, 8.28). In the adjusted linear regression model, three elements (Rb, Er, and Tm) in maternal hair and infant cord serum were negatively associated with Mental Development Index scores. For dietary exposures, elements were positively associated with noodles (Nb), sweetened beverages (Rb), poultry (Cs), oils and condiments (Ca), and other seafood (Gd). In addition, air pollutants PM2.5 (LUR) and PM10 were negatively associated with Ta and Re in maternal hair. CONCLUSIONS: Our findings highlight the potential influence of maternal element exposure on GDM risk and infant neurodevelopment. We identified links between levels of these elements in both maternal hair and infant cord serum related to air pollutants and dietary factors.
dc.description.confidentialfalse
dc.edition.editionOctober 2023
dc.format.pagination1875-1888
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37625317
dc.identifier.citationXia Y-Y, de Seymour JV, Yang X-J, Zhou L-W, Liu Y, Yang Y, Beck KL, Conlon CA, Mansell T, Novakovic B, Saffery R, Han T-L, Zhang H, Baker PN. (2023). Hair and cord blood element levels and their relationship with air pollution, dietary intake, gestational diabetes mellitus, and infant neurodevelopment.. Clin Nutr. 42. 10. (pp. 1875-1888).
dc.identifier.doi10.1016/j.clnu.2023.08.009
dc.identifier.eissn1532-1983
dc.identifier.elements-typejournal-article
dc.identifier.issn0261-5614
dc.identifier.piiS0261-5614(23)00261-3
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69907
dc.languageeng
dc.publisherElsevier B.V.
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0261561423002613
dc.relation.isPartOfClin Nutr
dc.rights(c) 2023 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAir pollutant exposures
dc.subjectGestational diabetes mellitus
dc.subjectHair elements
dc.subjectInductively coupled plasma-mass spectrometry
dc.subjectInfant neurodevelopment
dc.subjectMaternal diet
dc.subjectPregnancy
dc.subjectInfant
dc.subjectFemale
dc.subjectHumans
dc.subjectDiabetes, Gestational
dc.subjectCohort Studies
dc.subjectFetal Blood
dc.subjectAir Pollution
dc.subjectAir Pollutants
dc.subjectEating
dc.titleHair and cord blood element levels and their relationship with air pollution, dietary intake, gestational diabetes mellitus, and infant neurodevelopment.
dc.typeJournal article
pubs.elements-id479939
pubs.organisational-groupCollege of Health
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