The effect of dietary cadmium on kidney function in cats : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Animal Science at Massey University, Palmerston North, New Zealand

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dc.contributor.authorAnderson, Jeanette M J
dc.date.accessioned2017-10-19T01:29:28Z
dc.date.available2017-10-19T01:29:28Z
dc.date.issued2017
dc.description.abstractDue to the requirement for meat in feline diets, this study aimed to investigate the potential effects on kidney function in cats of cadmium accumulation in meat products due to pasture management practices. Cadmium may be a causal factor in feline Chronic Kidney Disease (CKD). Twenty-seven domestic short hair cats were randomly selected from the colony population of the Feline Nutrition Unit of Massey University and assigned to three experimental groups (n=9), which were balanced for age and sex. Each group received one of the three experimental diets designed to represent the full range of potential cadmium concentrations that cats may be exposed to on wet diets in New Zealand. Diets were fed ad libitum for a 6-month period. Kidney function was examined at baseline and after 3 and 6 months by measuring glomerular filtration rate (GFR) using iohexol clearance analysed by high performance liquid chromatography (HPLC). Blood and urine analyses were also conducted on a monthly basis. While GFR fluctuated over the study period no significant differences were found either between groups at the end, or within each group when compared at the beginning and end of the study. Although overall no evidence of CKD was observed, an unexplained trend of weight loss was observed in females receiving the two diets containing the highest cadmium levels, which may simply have reflected reduced dietary palatability. The results of the study showed no detectable effects of feeding the three diets for 6 months; however, an extended trial period may be required to fully investigate the longer term effects of cadmium levels and other dietary factors on the development of CKD. In particular, more work is needed to explore the potential for genetic and/or functional differences in mechanisms which are involved in the transport, and/or deposition of cadmium, or are protective against cadmium toxicity in cats and to further define normal parameters and standard approaches in measuring GFR in cats.en_US
dc.identifier.urihttp://hdl.handle.net/10179/12168
dc.language.isoenen_US
dc.publisherMassey Universityen_US
dc.rightsThe Authoren_US
dc.subjectCadmiumen_US
dc.subjectPhysiological effecten_US
dc.subjectCatsen_US
dc.subjectDiseasesen_US
dc.subjectFeeding and feedsen_US
dc.subjectVeterinary nephrologyen_US
dc.subjectResearch Subject Categories::VETERINARY MEDICINE::Physiology and nutritionen_US
dc.titleThe effect of dietary cadmium on kidney function in cats : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Animal Science at Massey University, Palmerston North, New Zealanden_US
dc.typeThesisen_US
massey.contributor.authorAnderson, Jeanette M J
thesis.degree.disciplineAnimal Scienceen_US
thesis.degree.grantorMassey Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Science (MSc)en_US
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