Comparative Effects of Co-Ingesting Whey Protein and Glucose Alone and Combined on Blood Glucose, Plasma Insulin and Glucagon Concentrations in Younger and Older Men

Simple item page
dc.citation.issue15
dc.citation.volume14
dc.contributor.authorOberoi A
dc.contributor.authorGiezenaar C
dc.contributor.authorRigda RS
dc.contributor.authorLange K
dc.contributor.authorHorowitz M
dc.contributor.authorJones KL
dc.contributor.authorChapman I
dc.contributor.authorSoenen S
dc.contributor.editorGropper S
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-10-17T19:30:55Z
dc.date.accessioned2023-10-19T20:38:35Z
dc.date.available2022-07-28
dc.date.available2023-10-17T19:30:55Z
dc.date.available2023-10-19T20:38:35Z
dc.date.issued2022-08
dc.date.updated2023-10-17T02:55:42Z
dc.description.abstractThe ingestion of dietary protein with, or before, carbohydrate may be a useful strategy to reduce postprandial hyperglycemia, but its effect in older people, who have an increased predisposition for type 2 diabetes, has not been clarified. Blood glucose, plasma insulin and glucagon concentrations were measured for 180 min following a drink containing either glucose (120 kcal), whey-protein (120 kcal), whey-protein plus glucose (240 kcal) or control (~2 kcal) in healthy younger (n = 10, 29 ± 2 years; 26.1 ± 0.4 kg/m2) and older men (n = 10, 78 ± 2 years; 27.3 ± 1.4 kg/m2). Mixed model analysis was used. In both age groups the co-ingestion of protein with glucose (i) markedly reduced the increase in blood glucose concentrations following glucose ingestion alone (p < 0.001) and (ii) had a synergistic effect on the increase in insulin concentrations (p = 0.002). Peak insulin concentrations after protein were unaffected by ageing, whereas insulin levels after glucose were lower in older than younger men (p < 0.05) and peak insulin concentrations were higher after glucose than protein in younger (p < 0.001) but not older men. Glucagon concentrations were unaffected by age. We conclude that the ability of whey-protein to reduce carbohydrate-induced postprandial hyperglycemia is retained in older men and that protein supplementation may be a useful strategy in the prevention and management of type 2 diabetes in older people.
dc.description.confidentialfalse
dc.edition.editionAugust 2022
dc.format.extent3111-
dc.identifier3111
dc.identifiernu14153111
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35956288
dc.identifier.citationOberoi A, Giezenaar C, Rigda RS, Lange K, Horowitz M, Jones KL, Chapman I, Soenen S. (2022). Comparative Effects of Co-Ingesting Whey Protein and Glucose Alone and Combined on Blood Glucose, Plasma Insulin and Glucagon Concentrations in Younger and Older Men.. Nutrients. 14. 15. (pp. 3111-).
dc.identifier.doi10.3390/nu14153111
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10179/20333
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2072-6643/14/15/3111
dc.relation.isPartOfNutrients
dc.rights(c) 2022 The Author/sen_US
dc.rightsCC BYen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectaging
dc.subjectblood glucose
dc.subjectdietary glucose
dc.subjectglucagon
dc.subjectinsulin
dc.subjectwhey protein
dc.subjectAged
dc.subjectBlood Glucose
dc.subjectDiabetes Mellitus, Type 2
dc.subjectGlucagon
dc.subjectGlucagon-Like Peptide 1
dc.subjectGlucose
dc.subjectHumans
dc.subjectHyperglycemia
dc.subjectInsulin
dc.subjectMale
dc.subjectPostprandial Period
dc.subjectWhey Proteins
dc.titleComparative Effects of Co-Ingesting Whey Protein and Glucose Alone and Combined on Blood Glucose, Plasma Insulin and Glucagon Concentrations in Younger and Older Men
dc.typeJournal article
pubs.elements-id455487
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
455487 PDF.pdf
Size:
718.52 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles