Postexercise muscle glycogen synthesis with glucose, galactose, and combined galactose-glucose ingestion.

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dc.citation.issue6
dc.citation.volume325
dc.contributor.authorPodlogar T
dc.contributor.authorShad BJ
dc.contributor.authorSeabright AP
dc.contributor.authorOdell OJ
dc.contributor.authorLord SO
dc.contributor.authorCivil R
dc.contributor.authorSalgueiro RB
dc.contributor.authorShepherd EL
dc.contributor.authorLalor PF
dc.contributor.authorElhassan YS
dc.contributor.authorLai Y-C
dc.contributor.authorRowlands DS
dc.contributor.authorWallis GA
dc.coverage.spatialUnited States
dc.date.accessioned2024-06-05T02:31:10Z
dc.date.available2024-06-05T02:31:10Z
dc.date.issued2023-12-01
dc.description.abstractIngested galactose can enhance postexercise liver glycogen repletion when combined with glucose but effects on muscle glycogen synthesis are unknown. In this double-blind randomized study participants [7 men and 2 women; V̇o2max: 51.1 (8.7) mL·kg-1·min-1] completed three trials of exhaustive cycling exercise followed by a 4-h recovery period, during which carbohydrates were ingested at the rate of 1.2 g·kg-1·h-1 comprising glucose (GLU), galactose (GAL) or galactose + glucose (GAL + GLU; 1:2 ratio). The increase in vastus lateralis skeletal-muscle glycogen concentration during recovery was higher with GLU relative to GAL + GLU [contrast: +50 mmol·(kg DM)-1; 95%CL 10, 89; P = 0.021] and GAL [+46 mmol·(kg DM)-1; 95%CL 8, 84; P = 0.024] with no difference between GAL + GLU and GAL [-3 mmol·(kg DM)-1; 95%CL -44, 37; P = 0.843]. Plasma glucose concentration in GLU was not significantly different vs. GAL + GLU (+ 0.41 mmol·L-1; 95%CL 0.13, 0.94) but was significantly lower than GAL (-0.75 mmol·L-1; 95%CL -1.34, -0.17) and also lower in GAL vs. GAL + GLU (-1.16 mmol·-1; 95%CL -1.80, -0.53). Plasma insulin was higher in GLU + GAL and GLU compared with GAL but not different between GLU + GAL and GLU. Plasma galactose concentration was higher in GAL compared with GLU (3.35 mmol·L-1; 95%CL 3.07, 3.63) and GAL + GLU (3.22 mmol·L-1; 95%CL 3.54, 2.90) with no difference between GLU + GAL (0.13 mmol·L-1; 95%CL -0.11, 0.37) and GLU. Compared with galactose or a galactose + glucose blend, glucose feeding was more effective in postexercise muscle glycogen synthesis. Comparable muscle glycogen synthesis was observed with galactose-glucose coingestion and exclusive galactose-only ingestion. NEW & NOTEWORTHY Postexercise galactose-glucose coingestion or exclusive galactose-only ingestion resulted in a lower rate of skeletal-muscle glycogen replenishment compared with exclusive glucose-only ingestion. Comparable muscle glycogen synthesis was observed with galactose-glucose coingestion and exclusive galactose-only ingestion.
dc.description.confidentialfalse
dc.format.paginationE672-E681
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37850935
dc.identifier.citationPodlogar T, Shad BJ, Seabright AP, Odell OJ, Lord SO, Civil R, Salgueiro RB, Shepherd EL, Lalor PF, Elhassan YS, Lai Y-C, Rowlands DS, Wallis GA. (2023). Postexercise muscle glycogen synthesis with glucose, galactose, and combined galactose-glucose ingestion.. Am J Physiol Endocrinol Metab. 325. 6. (pp. E672-E681).
dc.identifier.doi10.1152/ajpendo.00127.2022
dc.identifier.eissn1522-1555
dc.identifier.elements-typejournal-article
dc.identifier.issn0193-1849
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69734
dc.languageeng
dc.publisherAmerican Physiological Society
dc.publisher.urihttps://journals.physiology.org/doi/full/10.1152/ajpendo.00127.2022
dc.relation.isPartOfAm J Physiol Endocrinol Metab
dc.rights(c) The author/sen
dc.rights.licenseCC BYen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectexercise
dc.subjectnutrition
dc.subjectrecovery
dc.subjectsugars
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectBlood Glucose
dc.subjectDietary Carbohydrates
dc.subjectEating
dc.subjectGalactose
dc.subjectGlucose
dc.subjectGlycogen
dc.subjectInsulin
dc.subjectMuscle, Skeletal
dc.subjectDouble-Blind Method
dc.titlePostexercise muscle glycogen synthesis with glucose, galactose, and combined galactose-glucose ingestion.
dc.typeJournal article
pubs.elements-id480980
pubs.organisational-groupCollege of Health
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