Gastric protein digestion of cow, goat, and sheep milk is not reflected in the amino acid appearance in the blood of suckling piglets

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dc.citation.issue6
dc.citation.volume108
dc.contributor.authorRoy D
dc.contributor.authorMontoya CA
dc.contributor.authorStroebinger N
dc.contributor.authorHodgkinson SM
dc.contributor.authorYe A
dc.contributor.authorMcNabb WC
dc.contributor.authorMoughan PJ
dc.contributor.authorSingh H
dc.date.accessioned2025-05-28T02:17:45Z
dc.date.available2025-05-28T02:17:45Z
dc.date.issued2025-06
dc.description.abstractStructural changes in milk during gastric digestion are a key driving factor for the rate of digestion of nutrients in the gastrointestinal tract. Thus, the influence of gastric coagulation behavior on the kinetics of protein digestion of raw cow, goat, and sheep whole milk in the stomach was investigated using the 3-wk-old suckled male piglet as an animal model for human infants. Piglets received a single meal of fresh raw milk normalized for protein content, and were slaughtered at 0, 30, 90, 150, or 210 min postprandially. Gastric chyme and cardiac blood samples were collected. Gastric pepsin activity, rate of protein hydrolysis, and gastric emptying of AA were determined along with how these changes influence the appearance of AA in the plasma. The disappearance rates of individual proteins (especially β-LG and αS-CN), total digested proteins entering the small intestine, as well as the gastric emptying of some AA (proline, leucine) were (or tended to be) greater for goat and sheep milk than for cow milk. Differences in plasma concentrations for some AA (e.g., leucine) were observed across milk types, but they did not directly reflect changes in gastric protein digestion and the gastric emptying of AA. In conclusion, a combination of protein (and AA) composition, susceptibility of specific proteins to hydrolysis, and the nature of the curd structure formed influenced the digestion behavior of milk proteins in the stomach and their subsequent release into the small intestine.
dc.description.confidentialfalse
dc.edition.editionJune 2025
dc.format.pagination5598-5610
dc.identifier.citationRoy D, Montoya CA, Stroebinger N, Hodgkinson SM, Ye A, McNabb WC, Moughan PJ, Singh H. (2025). Gastric protein digestion of cow, goat, and sheep milk is not reflected in the amino acid appearance in the blood of suckling piglets. Journal of Dairy Science. 108. 6. (pp. 5598-5610).
dc.identifier.doi10.3168/jds.2024-25993
dc.identifier.eissn1525-3198
dc.identifier.elements-typejournal-article
dc.identifier.issn0022-0302
dc.identifier.piiS0022-0302(25)00202-4
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72969
dc.languageEnglish
dc.publisherElsevier Inc on behalf of the American Dairy Science Association
dc.publisher.urihttps://www.journalofdairyscience.org/article/S0022-0302(25)00202-4/fulltext
dc.relation.isPartOfJournal of Dairy Science
dc.rights(c) The author/sen
dc.rights.licenseCC BYen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectmilk of different species
dc.subjectgastric protein digestion
dc.subjectgastric emptying of amino acids
dc.subjectappearance of blood amino acids
dc.subjectpiglet model
dc.titleGastric protein digestion of cow, goat, and sheep milk is not reflected in the amino acid appearance in the blood of suckling piglets
dc.typeJournal article
pubs.elements-id500849
pubs.organisational-groupOther
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