The effects of diet and feeding on small intestinal development in piglets during the first 24 hours after birth : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Physiology and Anatomy at Massey University

Tungthanathanich, Prapaporn

The effects of diet and feeding on small intestinal development in piglets during the first 24 hours after birth : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Physiology and Anatomy at Massey University

dc.contributor.author	Tungthanathanich, Prapaporn
dc.date.accessioned	2010-05-13T20:40:30Z
dc.date.available	NO_RESTRICTION	en_US
dc.date.available	2010-05-13T20:40:30Z
dc.date.issued	1994
dc.description.abstract	To study the effects of feeding and diet on postnatal development of the small intestine in newborn piglets during the time 0 - 24 hours after birth, three studies were conducted: 1. Unsuckled newborn piglets were fed from a bottle with colostrum or milk from either sows or cows, infant formula, or water. After 24 hours intestinal development was compared with that in piglets at birth and others naturally suckled. Sow colostrum caused greater increases in weight and length of the small intestine than did any of the other diets. The increases were due to mucosal cell swelling caused by cellular protein accumulation, hyperplasia and, in the duodenum, hypertrophy. Feeding sow colostrum increased mucosal lactase activity. Cow colostrum caused decreases in mucosal RNA levels. Increases in the DNA content of the intestinal mucosa occurred in all groups, including the water fed group. Colostrum feeding also enhanced pancreatic growth and feeding infant formula increased liver weight. 2. The effects of enteral feeding on small intestinal development were investigated by feeding nutrient solution to unsuckled newborn piglets by orogastric tube or parenterally. Both groups after 24 hours had greater intestinal development than did the piglets at birth. The development was most pronounced in the duodenum and lower ileum. Apart from a greater small intestinal length in the orogastrically fed piglets there were no significant differences between the orogastrically and parenterally fed groups. 3. To investigate the effects of sucking per se on small intestinal development, groups of unsuckled piglets were fed for 24 hours with either sow colostrum or infant formula by orogastric tube or being allowed to suck from a bottle. Sucking did not affect intestinal development whereas colostrum, regardless of how it was fed, had significantly greater effects on intestinal development than did infant formula. For the colostrum fed piglets the intestinal length, tissue weight, circumference, wall thickness, villous height and width, RNA content, protein:DNA ratio and RNA:DNA ratio were all significantly greater than for those fed infant formula. In the duodenum the estimated cell migration rate was faster and mucosal cell replacement time was shorter than in other parts of the small intestine, regardless of the diet fed. The greater villous height in the piglets fed sow colostrum was most likely due to the combined effects of cellular swelling and an increase in the number of villous cells. These results indicate that (a) sow colostrum causes cellular swelling related to colostral protein accumulation, cell hyperplasia and, in the duodenum, hypertrophy, (b) there is a basal rate of mucosal cell division which contributes to mucosal growth regardless of diet and method of feeding, (c) the duodenum exhibits a greater growth and sensitivity to the trophic effects of colostrum compared to other parts of the small intestine, (d) feeding cow colostrum to newborn piglets causes a pronounced decrease in mucosal RNA content and (e) diets affect postnatal development of the small intestine whereas the route or method of feeding has no significant effects on small intestinal development in piglets during the first 24 hours after birth.	en_US
dc.identifier.uri	http://hdl.handle.net/10179/1304
dc.language.iso	en	en_US
dc.publisher	Massey University	en_US
dc.rights	The Author	en_US
dc.subject	Swine	en_US
dc.subject	Swine nutrition	en_US
dc.subject	Swine anatomy	en_US
dc.subject	Swine feed utilization efficiency	en_US
dc.subject.other	Fields of Research::270000 Biological Sciences::270600 Physiology::270603 Animal physiology-systems	en_US
dc.title	The effects of diet and feeding on small intestinal development in piglets during the first 24 hours after birth : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Physiology and Anatomy at Massey University	en_US
dc.type	Thesis	en_US
massey.contributor.author	Tungthanathanich, Prapaporn
thesis.degree.discipline	Physiology and anatomy	en_US
thesis.degree.grantor	Massey University	en_US
thesis.degree.level	Doctoral	en_US
thesis.degree.level	Doctoral	en
thesis.degree.name	Doctor of Philosophy (Ph.D.)	en_US