RETRACTED ARTICLE: Evaluating polymicrobial immune responses in patients suffering from tick-borne diseases

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dc.citation.volume8
dc.contributor.authorGarg K
dc.contributor.authorMerilainen L
dc.contributor.authorFranz O
dc.contributor.authorPirttinen H
dc.contributor.authorQuevedo-Diaz M
dc.contributor.authorCroucher S
dc.contributor.authorGilbert L
dc.date.available2018-10-29
dc.date.available2018-10-15
dc.date.issued2018-10-29
dc.description.abstractThere is insufficient evidence to support screening of various tick-borne diseases (TBD) related microbes alongside Borrelia in patients suffering from TBD. To evaluate the involvement of multiple microbial immune responses in patients experiencing TBD we utilized enzyme-linked immunosorbent assay. Four hundred and thirty-two human serum samples organized into seven categories followed Centers for Disease Control and Prevention two-tier Lyme disease (LD) diagnosis guidelines and Infectious Disease Society of America guidelines for post-treatment Lyme disease syndrome. All patient categories were tested for their immunoglobulin M (IgM) and G (IgG) responses against 20 microbes associated with TBD. Our findings recognize that microbial infections in patients suffering from TBDs do not follow the one microbe, one disease Germ Theory as 65% of the TBD patients produce immune responses to various microbes. We have established a causal association between TBD patients and TBD associated co-infections and essential opportunistic microbes following Bradford Hill’s criteria. This study indicated an 85% probability that a randomly selected TBD patient will respond to Borrelia and other related TBD microbes rather than to Borrelia alone. A paradigm shift is required in current healthcare policies to diagnose TBD so that patients can get tested and treated even for opportunistic infections
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448589200008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN 15932
dc.identifier.citationSCIENTIFIC REPORTS, 2018, 8
dc.identifier.doi10.1038/s41598-018-34393-9
dc.identifier.elements-id416717
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2045-2322
dc.publisherSpringer Nature Limited
dc.relation.isPartOfSCIENTIFIC REPORTS
dc.rights
dc.rights(c) The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleRETRACTED ARTICLE: Evaluating polymicrobial immune responses in patients suffering from tick-borne diseases
dc.typeJournal article
pubs.declined2023-02-03T10:05:26.753+1300
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/Massey Business School
pubs.organisational-group/Massey University/Massey Business School/School of Communication, Journalism and Marketing
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