Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline

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dc.citation.issue2
dc.citation.volume18
dc.contributor.authorRöhr S
dc.contributor.authorZülke A
dc.contributor.authorLuppa M
dc.contributor.authorBrettschneider C
dc.contributor.authorWeißenborn M
dc.contributor.authorKühne F
dc.contributor.authorZöllinger I
dc.contributor.authorSamos F-AZ
dc.contributor.authorBauer A
dc.contributor.authorDöhring J
dc.contributor.authorKrebs-Hein K
dc.contributor.authorOey A
dc.contributor.authorCzock D
dc.contributor.authorFrese T
dc.contributor.authorGensichen J
dc.contributor.authorHaefeli WE
dc.contributor.authorHoffmann W
dc.contributor.authorKaduszkiewicz H
dc.contributor.authorKönig H-H
dc.contributor.authorThyrian JR
dc.contributor.authorWiese B
dc.contributor.authorRiedel-Heller SG
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-11-22T22:18:00Z
dc.date.accessioned2024-07-25T06:50:31Z
dc.date.available2021-01-07
dc.date.available2023-11-22T22:18:00Z
dc.date.available2024-07-25T06:50:31Z
dc.date.issued2021-01
dc.description.abstractTargeting dementia prevention, first trials addressing multiple modifiable risk factors showed promising results in at-risk populations. In Germany, AgeWell.de is the first large-scale initiative investigating the effectiveness of a multi-component lifestyle intervention against cognitive decline. We aimed to investigate the recruitment process and baseline characteristics of the AgeWell.de participants to gain an understanding of the at-risk population and who engages in the intervention. General practitioners across five study sites recruited participants (aged 60–77 years, Cardiovascular Risk Factors, Aging, and Incidence of Dementia/CAIDE dementia risk score ≥ 9). Structured face-to-face interviews were conducted with eligible participants, including neuropsychological assessments. We analyzed group differences between (1) eligible vs. non-eligible participants, (2) participants vs. non-participants, and (3) between intervention groups. Of 1176 eligible participants, 146 (12.5%) dropped out before baseline; the study population was thus 1030 individuals. Non-participants did not differ from participants in key sociodemographic factors and dementia risk. Study participants were M = 69.0 (SD = 4.9) years old, and 52.1% were women. The average Montreal Cognitive Assessment/MoCA score was 24.5 (SD = 3.1), indicating a rather mildly cognitively impaired study population; however, 39.4% scored ≥ 26, thus being cognitively unimpaired. The bandwidth of cognitive states bears the interesting potential for differential trial outcome analyses. However, trial conduction is impacted by the COVID-19 pandemic, requiring adjustments to the study protocol with yet unclear methodological consequences.
dc.format.pagination1-15
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33430189
dc.identifier.citationRöhr S, Zülke A, Luppa M, Brettschneider C, Weißenborn M, Kühne F, Zöllinger I, Samos F-AZ, Bauer A, Döhring J, Krebs-Hein K, Oey A, Czock D, Frese T, Gensichen J, Haefeli WE, Hoffmann W, Kaduszkiewicz H, König H-H, Thyrian JR, Wiese B, Riedel-Heller SG. (2021). Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study-A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline.. Int J Environ Res Public Health. 18. 2. (pp. 1-15).
dc.identifier.doi10.3390/ijerph18020408
dc.identifier.eissn1660-4601
dc.identifier.elements-typejournal-article
dc.identifier.issn1661-7827
dc.identifier.piiijerph18020408
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70989
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfInt J Environ Res Public Health
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAgeWell.de
dc.subjectRCT
dc.subjectcluster-randomized controlled trial
dc.subjectcognitive function
dc.subjectdementia
dc.subjectgeneral practitioner
dc.subjectintervention
dc.subjectlifestyle
dc.subjectprevention
dc.subjectprimary care
dc.subjecttrial
dc.subjectAged
dc.subjectCognitive Dysfunction
dc.subjectFemale
dc.subjectGermany
dc.subjectHealthy Aging
dc.subjectHumans
dc.subjectLife Style
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeuropsychological Tests
dc.subjectPatient Selection
dc.titleRecruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline
dc.typeJournal article
pubs.elements-id455063
pubs.organisational-groupOther
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