Undiscovered Bat Hosts of Filoviruses.

Simple item page
dc.citation.issue7
dc.citation.volume10
dc.contributor.authorHan BA
dc.contributor.authorSchmidt JP
dc.contributor.authorAlexander LW
dc.contributor.authorBowden SE
dc.contributor.authorHayman DTS
dc.contributor.authorDrake JM
dc.date.available2016-07
dc.date.available2016-06-09
dc.date.issued2016-07
dc.description.abstractEbola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high biodiversity of potential hosts in temporally dynamic environments of equatorial Africa contributes to sporadic, unpredictable outbreaks that have hampered efforts to identify wild reservoirs for nearly 40 years. Using a machine learning algorithm, generalized boosted regression, we characterize potential filovirus-positive bat species with estimated 87% accuracy. Our model produces two specific outputs with immediate utility for guiding filovirus surveillance in the wild. First, we report a profile of intrinsic traits that discriminates hosts from non-hosts, providing a biological caricature of a filovirus-positive bat species. This profile emphasizes traits describing adult and neonate body sizes and rates of reproductive fitness, as well as species' geographic range overlap with regions of high mammalian diversity. Second, we identify several bat species ranked most likely to be filovirus-positive on the basis of intrinsic trait similarity with known filovirus-positive bats. New bat species predicted to be positive for filoviruses are widely distributed outside of equatorial Africa, with a majority of species overlapping in Southeast Asia. Taken together, these results spotlight several potential host species and geographical regions as high-probability targets for future filovirus surveillance.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000381017800026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN e0004815
dc.identifier.citationPLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (7)
dc.identifier.doi10.1371/journal.pntd.0004815
dc.identifier.elements-id271402
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1935-2735
dc.identifier.urihttps://hdl.handle.net/10179/10170
dc.relation.isPartOfPLOS NEGLECTED TROPICAL DISEASES
dc.subject.anzsrc06 Biological Sciences
dc.subject.anzsrc11 Medical and Health Sciences
dc.titleUndiscovered Bat Hosts of Filoviruses.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Undiscovered Bat Hosts of Filoviruses.pdf
Size:
1.83 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles