Genetic Association of PPARGC1A Gene Single Nucleotide Polymorphism with Milk Production Traits in Italian Mediterranean Buffalo.

Simple item page
dc.citation.volume2021
dc.contributor.authorHosseini SM
dc.contributor.authorTingzhu Y
dc.contributor.authorPasandideh M
dc.contributor.authorLiang A
dc.contributor.authorHua G
dc.contributor.authorFarmanullah
dc.contributor.authorSchreurs NM
dc.contributor.authorRaza SHA
dc.contributor.authorSalzano A
dc.contributor.authorCampanile G
dc.contributor.authorGasparrini B
dc.contributor.authorYang L
dc.contributor.editorKontos CK
dc.coverage.spatialUnited States
dc.date.accessioned2024-04-24T02:57:57Z
dc.date.accessioned2024-07-25T06:33:33Z
dc.date.available2021-03-18
dc.date.available2024-04-24T02:57:57Z
dc.date.available2024-07-25T06:33:33Z
dc.date.issued2021-03-20
dc.description.abstractPPARGC1A gene plays an important role in the activation of various important hormone receptors and transcriptional factors involved in the regulation of adaptive thermogenesis, gluconeogenesis, fiber-type switching in skeletal muscle, mitochondrial biogenesis, and adipogenesis, regulating the reproduction and proposed as a candidate gene for milk-related traits in cattle. This study identified polymorphisms in the PPARGC1A gene in Italian Mediterranean buffaloes and their associations to milk production and quality traits (lactation length, peak milk yield, fat and protein yield, and percentage). As a result, a total of seven SNPs (g.-78A>G, g.224651G>C, g.286986G>A, g.304050G>A, g.325647G>A, g.325817T>C, and g.325997G>A) were identified by DNA pooled sequencing. Analysis of productivity traits within the genotyped animals revealed that the g.286986G>A located at intron 4 was associated with milk production traits, but the g.325817T>C had no association with milk production. Polymorphisms in g.-78A>G was associated with peak milk yield and milk yield, while g.304050G>A and g.325997 G>A were associated with both milk yield and protein percentage. Our findings suggest that polymorphisms in the buffalo PPARGC1A gene are associated with milk production traits and can be used as a candidate gene for milk traits and marker-assisted selection in the buffalo breeding program.
dc.description.confidentialfalse
dc.format.pagination3653157-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33829059
dc.identifier.citationHosseini SM, Tingzhu Y, Pasandideh M, Liang A, Hua G, Farmanullah , Schreurs NM, Raza SHA, Salzano A, Campanile G, Gasparrini B, Yang L. (2021). Genetic Association of PPARGC1A Gene Single Nucleotide Polymorphism with Milk Production Traits in Italian Mediterranean Buffalo.. Biomed Res Int. 2021. (pp. 3653157-).
dc.identifier.doi10.1155/2021/3653157
dc.identifier.eissn2314-6141
dc.identifier.elements-typejournal-article
dc.identifier.issn2314-6133
dc.identifier.numberARTN 3653157
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70413
dc.languageeng
dc.publisherHindawi Limited
dc.publisher.urihttps://www.hindawi.com/journals/bmri/2021/3653157
dc.relation.isPartOfBiomed Res Int
dc.subjectAnimals
dc.subjectBuffaloes
dc.subjectGene Frequency
dc.subjectGenetic Association Studies
dc.subjectItaly
dc.subjectMilk
dc.subjectPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
dc.subjectPolymorphism, Single Nucleotide
dc.subjectQuantitative Trait, Heritable
dc.titleGenetic Association of PPARGC1A Gene Single Nucleotide Polymorphism with Milk Production Traits in Italian Mediterranean Buffalo.
dc.typeJournal article
pubs.elements-id444286
pubs.organisational-groupCollege of Health
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Published version
Size:
462.21 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles