Enhanced airway sensory nerve reactivity in non-eosinophilic asthma

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dc.citation.issue1
dc.citation.volume8
dc.contributor.authorAli H
dc.contributor.authorBrooks C
dc.contributor.authorCrane J
dc.contributor.authorBeasley R
dc.contributor.authorHolgate S
dc.contributor.authorGibson P
dc.contributor.authorPattemore P
dc.contributor.authorTzeng Y-C
dc.contributor.authorStanley T
dc.contributor.authorPearce N
dc.contributor.authorDouwes J
dc.date.accessioned2023-06-21T21:41:40Z
dc.date.available2021-11
dc.date.available2021-10-19
dc.date.available2023-06-21T21:41:40Z
dc.date.issued2021-11-02
dc.description© Author(s) (or their employer(s)) 2021.
dc.description.abstractBACKGROUND: Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics. METHODS: Thirty-eight asthmatics and 19 non-asthmatics (aged 14-21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5%. Airway hyperreactivity was defined as a ≥15% drop in FEV1 during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs. RESULTS: Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p<0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV1 was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed. CONCLUSION: NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000715379200004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN e000974
dc.identifier.citationBMJ OPEN RESPIRATORY RESEARCH, 2021, 8 (1)
dc.identifier.doi10.1136/bmjresp-2021-000974
dc.identifier.eissn2052-4439
dc.identifier.elements-id449365
dc.identifier.harvestedMassey_Dark
dc.publisherBMJ Publishing Group Ltd and the British Thoracic Society
dc.relation.isPartOfBMJ OPEN RESPIRATORY RESEARCH
dc.rightsCC BY-NC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectasthma
dc.subjectasthma mechanisms
dc.subjectasthma epidemiology
dc.subjectpaediatric asthma
dc.titleEnhanced airway sensory nerve reactivity in non-eosinophilic asthma
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/Research Centre for Hauora and Health
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