A blinded, placebo-controlled study on the clinical effects of vitamin E supplementation in dogs with osteoarthritis

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dc.citation.issue5
dc.citation.volume37
dc.contributor.authorGordon CL
dc.contributor.authorReeves SJ
dc.contributor.authorBurchell RK
dc.contributor.authorThomson C
dc.contributor.authorGal A
dc.contributor.authorLopez-Villalobos N
dc.contributor.authorWebster NSL
dc.contributor.authorLitster KM
dc.contributor.authorMitchell RAS
dc.coverage.spatialUnited States
dc.date.accessioned2024-12-09T20:41:10Z
dc.date.available2024-12-09T20:41:10Z
dc.date.issued2023-07-31
dc.description.abstractBACKGROUND: Vitamin E has a positive effect in the management of osteoarthritis in humans, and in a previous study of dogs. It has been suggested to decrease C-reactive protein concentrations and liver enzyme activities in humans and animals. OBJECTIVE: To assess the effect of vitamin E supplementation on lameness, pain, pain medication requirement, clinical pathology variables, and quality of life in large-breed dogs with naturally occurring osteoarthritis. ANIMALS: Fifty-seven client-owned dogs with naturally occurring osteoarthritis. METHODS: Dogs received either vitamin E or placebo for 90 days in a randomized, placebo-controlled, double-blinded, prospective clinical trial. Clinical lameness scores, pain medication requirements, and owner questionnaires were used to assess response to treatment every 30 days. Blood samples were collected at enrollment and at the end of the study period. RESULTS: Vitamin E administration did not improve pain, lameness, or quality of life as assessed by owners and veterinarians. Vitamin E supplementation did not decrease the requirement for rescue pain relief. No changes in clinical pathology variables were observed after 90 days of vitamin E supplementation. Body weight was negatively associated with the lameness scores and requirement for rescue pain relief. CONCLUSION: Vitamin E supplementation did not have any observable positive effects in dogs with naturally occurring osteoarthritis.
dc.description.confidentialfalse
dc.edition.editionSeptember 2023
dc.format.pagination1839-1847
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37522795
dc.identifier.citationGordon CL, Reeves SJ, Burchell RK, Thomson C, Gal A, Lopez-Villalobos N, Webster NSL, Litster KM, Mitchell RAS. (2023). A blinded, placebo-controlled study on the clinical effects of vitamin E supplementation in dogs with osteoarthritis.. J Vet Intern Med. 37. 5. (pp. 1839-1847).
dc.identifier.doi10.1111/jvim.16816
dc.identifier.eissn1939-1676
dc.identifier.elements-typejournal-article
dc.identifier.issn0891-6640
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72238
dc.languageeng
dc.publisherWiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine.
dc.publisher.urihttps://onlinelibrary.wiley.com/doi/10.1111/jvim.16816
dc.relation.isPartOfJ Vet Intern Med
dc.rights(c) The author/sen
dc.rights.licenseCC BYen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectarthritis
dc.subjectinflammation
dc.subjectlameness
dc.subjectnutraceutical
dc.subjectAnimals
dc.subjectDogs
dc.subjectDietary Supplements
dc.subjectDog Diseases
dc.subjectLameness, Animal
dc.subjectOsteoarthritis
dc.subjectPain
dc.subjectProspective Studies
dc.subjectAnimal Welfare
dc.titleA blinded, placebo-controlled study on the clinical effects of vitamin E supplementation in dogs with osteoarthritis
dc.typeJournal article
pubs.elements-id479721
pubs.organisational-groupOther
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