Social Isolation and Incident Dementia in the Oldest-Old—A Competing Risk Analysis

Simple item page
dc.citation.volume13
dc.contributor.authorGrothe J
dc.contributor.authorRöhr S
dc.contributor.authorLuppa M
dc.contributor.authorPabst A
dc.contributor.authorKleineidam L
dc.contributor.authorHeser K
dc.contributor.authorFuchs A
dc.contributor.authorPentzek M
dc.contributor.authorOey A
dc.contributor.authorWiese B
dc.contributor.authorLühmann D
dc.contributor.authorvan den Bussche H
dc.contributor.authorWeyerer S
dc.contributor.authorWerle J
dc.contributor.authorWeeg D
dc.contributor.authorBickel H
dc.contributor.authorScherer M
dc.contributor.authorKönig H-H
dc.contributor.authorHajek A
dc.contributor.authorWagner M
dc.contributor.authorRiedel-Heller SG
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-01-30T00:12:05Z
dc.date.accessioned2024-07-25T06:37:07Z
dc.date.available2022-06-10
dc.date.available2024-01-30T00:12:05Z
dc.date.available2024-07-25T06:37:07Z
dc.date.issued2022-06
dc.description.abstractPurpose: Social isolation is considered a risk factor for dementia. However, less is known about social isolation and dementia with respect to competing risk of death, particularly in the oldest-old, who are at highest risk for social isolation, dementia and mortality. Therefore, we aimed to examine these associations in a sample of oldest-old individuals. Methods: Analyses were based on follow-up (FU) 5–9 of the longitudinal German study AgeCoDe/AgeQualiDe. Social isolation was assessed using the short form of the Lubben Social Network Scale (LSNS-6), with a score ≤ 12 indicating social isolation. Structured interviews were used to identify dementia cases. Competing risk analysis based on the Fine-Gray model was conducted to test the association between social isolation and incident dementia. Results: Excluding participants with prevalent dementia, n = 1,161 individuals were included. Their mean age was 86.6 (SD = 3.1) years and 67.0% were female. The prevalence of social isolation was 34.7% at FU 5, 9.7% developed dementia and 36.0% died during a mean FU time of 4.3 (SD = 0.4) years. Adjusting for covariates and cumulative mortality risk, social isolation was not significantly associated with incident dementia; neither in the total sample (sHR: 1.07, 95%CI 0.65-1.76, p = 0.80), nor if stratified by sex (men: sHR: 0.71, 95%CI 0.28-1.83, p = 0.48; women: sHR: 1.39, 95%CI 0.77-2.51, p = 0.27). Conclusion: In contrast to the findings of previous studies, we did not find an association between social isolation and incident dementia in the oldest-old. However, our analysis took into account the competing risk of death and the FU period was rather short. Future studies, especially with longer FU periods and more comprehensive assessment of qualitative social network characteristics (e.g., loneliness and satisfaction with social relationships) may be useful for clarification.
dc.format.pagination834438-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35757202
dc.identifier.citationGrothe J, Röhr S, Luppa M, Pabst A, Kleineidam L, Heser K, Fuchs A, Pentzek M, Oey A, Wiese B, Lühmann D, van den Bussche H, Weyerer S, Werle J, Weeg D, Bickel H, Scherer M, König H-H, Hajek A, Wagner M, Riedel-Heller SG. (2022). Social Isolation and Incident Dementia in the Oldest-Old-A Competing Risk Analysis.. Front Psychiatry. 13. (pp. 834438-).
dc.identifier.doi10.3389/fpsyt.2022.834438
dc.identifier.eissn1664-0640
dc.identifier.elements-typejournal-article
dc.identifier.issn1664-0640
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70550
dc.languageeng
dc.publisherFrontiers Media S.A
dc.relation.isPartOfFront Psychiatry
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectcompeting risk analysis
dc.subjectepidemiology
dc.subjectincident dementia
dc.subjectlongitudinal study
dc.subjectoldest-old
dc.subjectsocial isolation
dc.titleSocial Isolation and Incident Dementia in the Oldest-Old—A Competing Risk Analysis
dc.typeJournal article
pubs.elements-id455068
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Published
Size:
515.89 KB
Format:
Adobe Portable Document Format
Description:
Download
Thumbnail Image
Name:
Evidence
Size:
330.05 KB
Format:
Microsoft Word XML
Description:
Download
Collections
Journal Articles