Journal Articles

Permanent URI for this collectionhttps://mro.massey.ac.nz/handle/10179/7915

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    Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities
    (Springer Nature Limited, 2019-12-20) Migliavacca E; Tay SKH; Patel HP; Sonntag T; Civiletto G; McFarlane C; Forrester T; Barton SJ; Leow MK; Antoun E; Charpagne A; Seng Chong Y; Descombes P; Feng L; Francis-Emmanuel P; Garratt ES; Giner MP; Green CO; Karaz S; Kothandaraman N; Marquis J; Metairon S; Moco S; Nelson G; Ngo S; Pleasants T; Raymond F; Sayer AA; Ming Sim C; Slater-Jefferies J; Syddall HE; Fang Tan P; Titcombe P; Vaz C; Westbury LD; Wong G; Yonghui W; Cooper C; Sheppard A; Godfrey KM; Lillycrop KA; Karnani N; Feige JN
    The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. Here, we compare genome-wide transcriptional changes of sarcopenia versus age-matched controls in muscle biopsies from 119 older men from Singapore, Hertfordshire UK and Jamaica. Individuals with sarcopenia reproducibly demonstrate a prominent transcriptional signature of mitochondrial bioenergetic dysfunction in skeletal muscle, with low PGC-1α/ERRα signalling, and downregulation of oxidative phosphorylation and mitochondrial proteostasis genes. These changes translate functionally into fewer mitochondria, reduced mitochondrial respiratory complex expression and activity, and low NAD+ levels through perturbed NAD+ biosynthesis and salvage in sarcopenic muscle. We provide an integrated molecular profile of human sarcopenia across ethnicities, demonstrating a fundamental role of altered mitochondrial metabolism in the pathological loss of skeletal muscle mass and function in older people.
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    Opening accounting: a Manifesto
    (Taylor and Francis Group on behalf of the University of South Australia, 2021-07-21) Alawattage C; Arjaliès D-L; Barrett M; Bernard J; de Castro Casa Nova SP; Cho CH; Cooper C; Denedo M; D’Astros CD; Evans R; Ejiogu A; Frieden L; Ghio A; McGuigan N; Luo Y; Pimentel E; Powell L; Pérez PAN; Quattrone P; Romi AM; Smyth S; Sopt J; Sorola M; Alawattage C; Arjaliès D-L; Barrett M; Bernard J; de Castro Casa Nova SP; Cho CH; Cooper C; Denedo M; D’Astros CD; Evans R; Ejiogu A; Frieden L; Ghio A; McGuigan N; Luo Y; Pimentel E; Powell L; Pérez PAN; Quattrone P; Romi AM; Smyth S; Sopt J; Sorola M