Journal Articles

Permanent URI for this collectionhttps://mro.massey.ac.nz/handle/10179/7915

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Has files: YesSubject: search.filters.subject.viral oncogenesis

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    First report of a papillomavirus-induced viral plaque in the mouth of a dog
    (John Wiley and Sons Ltd on behalf of ESVD and ACVD, 2025-05-15) Munday JS; Hobson P; Bell CM
    Canis familiaris papillomavirus type 16 was amplified from a mass in the mouth of a dog. The mass was histologically consistent with a pigmented viral plaque. This is the first report of an oral viral plaque in a dog. Histological investigation is essential to allow differentiation from an oral melanoma.
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    Amplification of Ovis aries papillomavirus type 2 DNA from an ovine cutaneous fibropapilloma.
    (John Wiley and Sons, Inc., 2024-04-01) Munday JS; Klobukowska HJ; Nicholson K
    Seven of 60 Perendale sheep within a flock developed single or multiple exophytic masses on their distal hind limbs. A mass was excised from one sheep and histological evaluation revealed epidermal and mesenchymal proliferation, papillomavirus-induced keratinocyte changes and marked keratohyalin clumping. Ovis aries papillomavirus type 2 DNA sequences were amplified using PCR.
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    Detection of a novel papillomaviral sequence in viral plaques confined to the pinna of a dog.
    (John Wiley and Sons, Inc., 2023-08-01) Munday JS; Orbell G; Robinson L
    A raised plaque that contained histological evidence of papillomavirus infection and sequences from a novel papillomavirus type developed close to the ear canal of a 14-year-old West Highland white terrier. The plaque was excised, and further plaques developed within the same area of pinna.
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    Papillomaviruses in Domestic Cats
    (MDPI (Basel, Switzerland), 2021-08-22) Munday JS; Thomson NA; Beatty JA; Tasker S
    Papillomaviruses (PVs) are well established to cause hyperplastic papillomas (warts) in humans and animals. In addition, due to their ability to alter cell regulation, PVs are also recognized to cause approximately 5% of human cancers and these viruses have been associated with neoplasia in a number of animal species. In contrast to other domestic species, cats have traditionally been thought to less frequently develop disease due to PV infection. However, in the last 15 years, the number of viruses and the different lesions associated with PVs in cats have greatly expanded. In this review, the PV life cycle and the subsequent immune response is briefly discussed along with methods used to investigate a PV etiology of a lesion. The seven PV types that are currently known to infect cats are reviewed. The lesions that have been associated with PV infections in cats are then discussed and the review finishes with a brief discussion on the use of vaccines to prevent PV-induced disease in domestic cats.
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    Identification of Felis catus papillomavirus 3 in skin neoplasms from four cats.
    (2018-03) Munday JS; Thomson NA; Henderson G; Fairley R; Orbell GM
    Bowenoid in situ carcinomas (BISCs) are papillomavirus (PV)-induced skin neoplasms that are thought to be caused by Felis catus papillomavirus (FcaPV) 2. As BISCs are typically multiple and can become extensive, they can be difficult to treat. Herein we describe 4 cats that developed skin neoplasms that contained FcaPV-3 DNA. One cat developed multiple basal cell carcinomas (BCCs), 1 a BISC with unusual extension into hair follicles, and 2 developed a single typical-appearing BISC. All neoplasms contained prominent PV-induced cell changes and intense p16CDKN2a protein immunostaining. Results from these 4 cats provide evidence that FcaPV-3 could cause a proportion of feline skin cancers, albeit less frequently than FcaPV-2. Excision of the typical BISCs and the BCCs appeared curative. Although the cat with the unusual BISC was euthanized because of the large size of the lesion, evidence from these 4 cats suggests that skin neoplasms that contain FcaPV-3 DNA may have a less aggressive clinical behavior than those associated with FcaPV-2. A consistent feature of the neoplasms in all 4 cats was the presence of prominent basophilic intracytoplasmic inclusion bodies; these inclusions have not been reported in lesions caused by FcaPV-2, to our knowledge, and their detection may allow differentiation between the different PV types and could therefore be a useful prognostic feature.