Journal Articles

Permanent URI for this collectionhttps://mro.massey.ac.nz/handle/10179/7915

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    Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on electrolyte and acid-base variables in dogs with suspected intracranial hypertension
    (Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine, 2021-01-31) Hoehne SN; Yozova ID; Vodondo B; Adamik KN
    Background Hyperosmolar agents frequently are used to decrease intracranial pressure but their effects on electrolyte and acid-base variables have not been prospectively investigated. Objectives Compare duration and magnitude of changes in electrolyte and acid-base variables after hyperosmolar treatment. Animals Twenty-eight client-owned dogs with intracranial hypertension caused by various pathologies. Methods Prospective, randomized, nonblinded, experimental cohort study. Fifteen dogs received a single dose (4 mL/kg) of 7.2% hypertonic saline (HTS), 13 dogs received 20% mannitol (MAN) 1 g/kg IV. Electrolyte and acid-base variables were measured before (T0), and 5 (T5), 60 (T60), and 120 (T120) minutes after administration. Variables were compared between treatments and among time points within treatment groups. Results Mean plasma sodium and chloride concentrations were higher after HTS than MAN at T5 (158 vs 141 mEq/L; 126 vs 109 mEq/L) and significant differences were maintained at all time points. After HTS, plasma sodium and chloride concentrations remained increased from T0 at all time points. After MAN, plasma sodium and chloride concentrations decreased at T5, but these changes were not maintained at T60 and T120. Plasma potassium concentration was lower at T5 after HTS compared with T0 (3.6 vs 3.9 mEq/L) and compared to MAN (3.6 vs 4.1 mEq/L). At T60 and T120, plasma ionized calcium concentration was lower after HTS than MAN (1.2 vs 1.3 mmol/L). No significant differences were found in acid-base variables between treatments. Conclusions and Clinical Importance At the administered dose, dogs receiving HTS showed sustained increases in plasma sodium and chloride concentrations, whereas dogs receiving MAN showed transient decreases. Future studies should assess the effects of multiple doses of hyperosmolar agents on electrolyte and acid-base variables.
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    Development of Two Types of Isotonic Beverages with Functional Attributes Using Natural and Synthetic Ingredients
    (Faculty of Science, University of Peradeniya, Sri Lanka, 2024-04-23) Kariyawasam KP; Somaratne GM; Roy D; Silva DD; Weththasinghe WAOW; Sandanika DWN
    Isotonic drinks maintain a balance of salt and sugar concentrations similar to that of the human body, aiding in the rapid replacement of lost fluids during dehydration. Although the availability of isotonic beverages in the Sri Lankan market is limited, this segment is experiencing rapid growth on the global stage, with numerous brands marketing their products. Moreover, it is especially advantageous to create isotonic beverages tailored to tropical country consumers, given their ability to effectively replenish lost fluids due to dehydration. This study seeks to develop economically viable and commercially feasible formulations of isotonic drinks that cater to the preferences of Sri Lankan consumers, utilizing a combination of synthetic and natural ingredients. In the realm of natural isotonic beverages, coconut water and bee honey serve as excellent sources of electrolytes and sugar, respectively. Following osmolality and sensory evaluations, the chosen samples underwent further analysis to determine their mineral content and physicochemical characteristics. These developed formulations fall within the prescribed ranges for osmolality (270-330 mOsm/kg) and sodium content (460-1150 mg. L-1), aligning with international standards for isotonic beverages. In conclusion, the devised formulas successfully adhere to international specifications for isotonic beverages. The abundant potential of coconut water and bee honey in Sri Lanka with wide availability as valuable sources of minerals and energy for crafting isotonic drinks is evident.