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dc.contributor.authorDaniels, NJen_US
dc.contributor.authorHyde, Een_US
dc.contributor.authorGhosh, Sen_US
dc.contributor.authorSeo, Ken_US
dc.contributor.authorPrice, KMen_US
dc.contributor.authorHoshino, Ken_US
dc.contributor.authorKaisho, Ten_US
dc.contributor.authorOkada, Ten_US
dc.contributor.authorRonchese, Fen_US
dc.date.available2016-01en_US
dc.date.available2015-05-19en_US
dc.date.issued2016-01en_US
dc.identifier.citationMucosal Immunology, 2016, 9 pp. 229 - 239 (11)en_US
dc.identifier.issn1935-3456en_US
dc.description.abstractAllergic airway inflammation is driven by the recognition of inhaled allergen by T helper type 2 (Th2) cells in the airway and lung. Allergen-specific cytotoxic T lymphocytes (CTLs) can strongly reduce airway inflammation, however, the mechanism of their inhibitory activity is not fully defined. We used mouse models to show that allergen-specific CTLs reduced early cytokine production by Th2 cells in lung, and their subsequent accumulation and production of interleukin (IL)-4 and IL-13. In addition, treatment with specific CTLs also increased the proportion of caspase+ dendritic cells (DCs) in mediastinal lymph node (MLN), and decreased the numbers of CD103+ and CD11b+ DCs in the lung. This decrease required expression of the cytotoxic mediator perforin in CTLs and of the appropriate MHC-antigen ligand on DCs, suggesting that direct CTL-DC contact was necessary. Lastly, lung imaging experiments revealed that in airway-challenged mice XCR1-GFP+ DCs, corresponding to the CD103+ DC subset, and XCR1-GFP− CD11c+ cells, which include CD11b+ DCs and alveolar macrophages, both clustered in the areas surrounding the small airways and were closely associated with allergen-specific CTLs. Thus, allergen-specific CTLs reduce allergic airway inflammation by depleting CD103+ and CD11b+ DC populations in the lung, and may constitute a mechanism through which allergic immune responses are regulated.en_US
dc.format.extent229 - 239 (11)en_US
dc.publisherNature Publishing Groupen_US
dc.relation.replaceshttp://hdl.handle.net/123456789/2969
dc.relation.replaces123456789/2969
dc.relation.urihttp://www.nature.com/mi/journal/v9/n1/full/mi201555a.htmlen_US
dc.subjectImmunologyen_US
dc.subjectDendritic cellsen_US
dc.subjectFlow cytometryen_US
dc.subjectRNAen_US
dc.subjectCytotoxicityen_US
dc.subjectCTLen_US
dc.subjectT lymphocytesen_US
dc.subjectCD103+en_US
dc.subjectCD11b+en_US
dc.subjectantigenen_US
dc.subjectantibodyen_US
dc.titleAntigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammationen_US
dc.typeJournal Article
dc.citation.volume9en_US
dc.identifier.doi10.1038/mi.2015.55en_US
dc.description.confidentialfalseen_US
dc.identifier.elements-id280296
dc.relation.isPartOfMucosal Immunologyen_US
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
dc.identifier.harvestedMassey_Dark
pubs.notesNot knownen_US
dc.subject.anzsrc06 Biological Sciencesen_US
dc.subject.anzsrc11 Medical And Health Sciencesen_US


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