Collagen dehydration
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Date
2022-09-01
Open Access Location
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier BV
Rights
(c) The Author/s
CC BY 4.0
Abstract
Type I collagen is a ubiquitous structural protein in animal tissues. It is normally present in a hydrated form. However, collagen is very dependent on associated water for its mechanical properties. In skin, where type I collagen is dominant, there is a longstanding concern that the skin and therefore collagen may partially dry out and result in structural degradation. Here we show that dehydration of type I collagen fibrils, using 2-propanol, results in a two-stage dehydration process. Initially, the fibrils do not change length, i.e. the D-period remains constant, but shrinkage occurs within the fibrils by an increase in the gap region and a decrease in the overlap region within a D-band and a shortening of the helical turn distance and fibril diameter. Only with further dehydration does the length of the collagen fibril decrease (a decrease in D-period). This mechanism explains why collagen materials are resistant to gross structural change in the early stages of dehydration and shows why they may then suffer from sudden external shrinkage with further dehydration.
Description
Keywords
Collagen, Dehydration, Small angle X-ray scattering, Animals, Collagen, Collagen Type I, Dehydration, Extracellular Matrix, Skin
Citation
Int J Biol Macromol, 2022, 216 pp. 140 - 147