Parity and the risk of incident dementia: a COSMIC study
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Date
2020-10-20
Open Access Location
Journal Title
Journal ISSN
Volume Title
Publisher
Cambridge University Press
Rights
(c) 2020 The Author/s
CC BY-NC-SA 4.0
CC BY-NC-SA 4.0
Abstract
Aims
To investigate the association between parity and the risk of incident dementia in women.
Methods
We pooled baseline and follow-up data for community-dwelling women aged 60 or older from six population-based, prospective cohort studies from four European and two Asian countries. We investigated the association between parity and incident dementia using Cox proportional hazards regression models adjusted for age, educational level, hypertension, diabetes mellitus and cohort, with additional analysis by dementia subtype (Alzheimer dementia (AD) and non-Alzheimer dementia (NAD)).
Results
Of 9756 women dementia-free at baseline, 7010 completed one or more follow-up assessments. The mean follow-up duration was 5.4 ± 3.1 years and dementia developed in 550 participants. The number of parities was associated with the risk of incident dementia (hazard ratio (HR) = 1.07, 95% confidence interval (CI) = 1.02–1.13). Grand multiparity (five or more parities) increased the risk of dementia by 30% compared to 1–4 parities (HR = 1.30, 95% CI = 1.02–1.67). The risk of NAD increased by 12% for every parity (HR = 1.12, 95% CI = 1.02–1.23) and by 60% for grand multiparity (HR = 1.60, 95% CI = 1.00–2.55), but the risk of AD was not significantly associated with parity.
Conclusions
Grand multiparity is a significant risk factor for dementia in women. This may have particularly important implications for women in low and middle-income countries where the fertility rate and prevalence of grand multiparity are high.
Description
Keywords
Dementia, geriatric psychiatry, risk factors, women, Aged, Aged, 80 and over, Alzheimer Disease, China, Cohort Studies, Dementia, Europe, Female, Geriatric Psychiatry, Humans, Incidence, Independent Living, Middle Aged, Parity, Pregnancy, Proportional Hazards Models, Republic of Korea, Risk Factors, Socioeconomic Factors
Citation
Bae JB, Lipnicki DM, Han JW, Sachdev PS, Kim TH, Kwak KP, Kim BJ, Kim SG, Kim JL, Moon SW, Park JH, Ryu S-H, Youn JC, Lee DY, Lee DW, Lee SB, Lee JJ, Jhoo JH, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Dardiotis E, Riedel-Heller S, Roehr S, Pabst A, Ding D, Zhao Q, Liang X, Lobo A, De-la-Cámara C, Lobo E, Kim KW, for Cohort Studies of Memory in an International Consortium (COSMIC) . (2020). Parity and the risk of incident dementia: a COSMIC study.. Epidemiol Psychiatr Sci. 29. (pp. e176-).